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MAP2K6 antibody (Mitogen-Activated Protein Kinase Kinase 6) (pSer207)

Details for Product anti-MAP2K6 Antibody No. ABIN196865, Supplier: Login to see New
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(50), (34), (15), (7), (6), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Human, Rat (Rattus)
(168), (98), (79), (3), (2), (2)
(165), (24), (2)
This MAP2K6 antibody is un-conjugated
(4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(152), (71), (63), (42), (27), (24), (14), (10), (7), (3), (2), (1)
Pubmed 2 references available
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Quantity 50 μL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthetic phosphopeptide derived from Human MKK6 around the phosphorylation site of Serine 207 (V-D-Sp-V-A).
Specificity This antibody detects endogenous levels of MKK6 only when phosphorylated at serine207.
Purification Immunoaffinity Chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name MAP2K6 (MAP2K6 Antibody Abstract)
Background Mitogen activated protein kinase kinase 6 (MEK6 or MKK6) belongs to the serine/threonine protein kinase family and the MAPK kinase subfamily (MAP2K, MKK or MEKs). MEK6, closely related to MEK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in MAP kinase p38, thus activating it, in response to inflammatory cytokines and environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this protein is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.Synonyms: Dual specificity mitogen-activated protein kinase kinase 6, MAP kinase kinase 6, MAPK/ERK kinase 6, MAPKK 6, MEK6, MKK6, SAPKK3
Gene ID 5608
NCBI Accession NP_002749
UniProt P52564
Research Area Kinases/Phosphatases
Pathways MAPK Signaling, TLR Signaling
Application Notes Suitable for use in Western blot (1: 500approx. 1: 1000) and Immunohistochemistry (1: 50approx. 1: 100).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C.
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Background publications Wang, Chen, Liao et al.: "Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence." in: Molecular and cellular biology, Vol. 22, Issue 10, pp. 3389-403, 2002 (PubMed).

Raingeaud, Whitmarsh, Barrett et al.: "MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway." in: Molecular and cellular biology, Vol. 16, Issue 3, pp. 1247-55, 1996 (PubMed).

Catalog No. ABIN196865
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