GZMA antibody

Catalog No. ABIN198300

The Mouse Monoclonal anti-GZMA antibody (Clone GA6) (ABIN198300) specifically detects GZMA in WB, IHC and IHC (p). The antibody is reactive with Human samples.

Quick Overview for GZMA antibody (ABIN198300)

Target: GZMA (Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GZMA antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: GA6

Product Details anti-GZMA Antibody

Specificity: Recognizes Granzyme A, a 60kD disulphide-linked homodimeric protein expressed in cytoplasmic granules of cytotoxic lymphocytes. The biological function of Granzyme A is unclear. It would appear that the molecule may have a role in the induction of apoptosis via its activity as a serine protease, but this would seem to be subsidiary to the role of Granzyme B. Granzyme A deficient mice are indistinguishable from normal animals in their response to infection.

Purification: Affinity purified

Immunogen: Recombinant human granzyme A.

Type of Immunogen: Recombinant protein

Isotype: IgG1

Application Details

Application Notes: Approved: IHC, IHC-P (1:50 - 1:200), WB

Usage: Immunohistology: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer  pH 6.0 is recommended for this purpose.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing. Store undiluted.

Storage: 4 °C,-20 °C

Storage Comment: 4°C or -20°C, Avoid freeze-thaw cycles. Store undiluted.

Target Details for GZMA

Target: GZMA (Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA))

Alternative Name: GZMA / Granzyme A

Background: Name/Gene ID: GZMA
Subfamily: Serine S1
Family: Protease

Synonyms: GZMA, CTLA3, CTL tryptase, Granzyme-1, H factor, HF, HFSP, Granzyme A, Fragmentin-1, Hanukah factor, Hanukkah factor

Gene ID: 3001

Pathways: Apoptosis