RYR1 antibody (AA 1-534) (HRP)

Catalog No. ABIN1993995

Product Details anti-RYR1 Antibody (HRP)

Target: RYR1 (Ryanodine Receptor 1 (Skeletal) (RYR1))

Binding Specificity: AA 1-534

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RYR1 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Ryanodine receptor 1 protein (1-534AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin^TM: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze.
Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RYR1

Target: RYR1 (Ryanodine Receptor 1 (Skeletal) (RYR1))

Alternative Name: RYR1 (RYR1 Products)

Synonyms: ryr1 antibody, RYR1 antibody, alphaRYR antibody, CCO antibody, MHS antibody, MHS1 antibody, RYDR antibody, RYR antibody, RYR-1 antibody, SKRR antibody, Ryr1l antibody, CRC antibody, AI528790 antibody, Ryr antibody, skrr antibody, ryanodine receptor 1 antibody, ryanodine receptor 1 (skeletal) antibody, ryanodine receptor 1a (skeletal) antibody, ryanodine receptor 1, skeletal muscle antibody, RYR1 antibody, ryr1a antibody, Ryr1 antibody

Background:

Background: Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca2+ leaking into the cytoplasm. Can also mediate the release of Ca2+ from intracellular stores in neurons, and may thereby promote prolonged Ca2+ signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis

Aliases: CCO antibody, Central core disease of muscle antibody, MHS antibody, MHS1 antibody, PPP1R137 antibody, Protein phosphatase 1 regulatory subunit 137 antibody, Ryanodine receptor 1 antibody, RYDR antibody, RYR antibody, RYR-1 antibody, RyR1 antibody, RYR1_HUMAN antibody, sarcoplasmic reticulum calcium release channel antibody, Skeletal muscle calcium release channel antibody, Skeletal muscle ryanodine receptor antibody, Skeletal muscle-type ryanodine receptor antibody, SKRR antibody, Type 1 ryanodine receptor antibody

UniProt: P21817

Pathways: Myometrial Relaxation and Contraction, Skeletal Muscle Fiber Development