D2HGDH antibody (N-Term)

Catalog No. ABIN2156668

This Rabbit Polyclonal antibody specifically detects D2HGDH in WB. It exhibits reactivity toward Human, Zebrafish (Danio rerio), Mouse, Rat, Rabbit, Dog, Horse, Cow and Guinea Pig.

Quick Overview for D2HGDH antibody (N-Term) (ABIN2156668)

Target: D2HGDH (D-2-Hydroxyglutarate Dehydrogenase (D2HGDH))

Reactivity: Human, Zebrafish (Danio rerio), Mouse, Rat, Rabbit, Dog, Horse, Cow, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This D2HGDH antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-D2HGDH Antibody

Binding Specificity: N-Term

Sequence: AFERIVPGGV VTDPEALQAP NVDWLRTLRG CSKVLLRPRT SEEVSHILRH

Predicted Reactivity: Cow: 79%, Dog: 92%, Guinea Pig: 85%, Horse: 79%, Human: 100%, Mouse: 86%, Rabbit: 92%, Rat: 93%, Zebrafish: 77%

Characteristics: This is a rabbit polyclonal antibody against D2HGDH. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human D2HGDH

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for D2HGDH

Target: D2HGDH (D-2-Hydroxyglutarate Dehydrogenase (D2HGDH))

Alternative Name: D2HGDH

Background: This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features.
Alias Symbols: D2HGD
Protein Size: 325

Molecular Weight: 35 kDa

Gene ID: 728294

NCBI Accession: NM_001287249, NP_001274178

UniProt: Q8N465