TNFRSF4 antibody (FITC)

Catalog No. ABIN225579

Product Details anti-TNFRSF4 Antibody (FITC)

Target: TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))

Reactivity: Cat

Host: Mouse

Clonality: Monoclonal

Conjugate: This TNFRSF4 antibody is conjugated to FITC

Application: Western Blotting (WB), Flow Cytometry (FACS)

Specificity: Recognizes feline CD134, otherwise known as OX40, a 43kD type I membrane protein and member of the tumor necrosis factor receptor superfamily, expressed predominantly by CD4+ activated T cells, and a key regulator of T cell-dependent immune responses. CD134 has been identified as the receptor for the OX40 ligand, CD252, expressed by activated B cells, acting as a co-stimulatory signal for the stimulation and secretion of immunoglobulins. CD134 has also been identified as a binding receptor for Feline Immunodeficiency Virus (FIV), acting along with CXC chemokine receptor 4 (CXCR4) to facilitate the entry of the virus into CD4+ primary target cells.

No Cross-Reactivity: Mouse (Murine)

Purification: Protein G purified

Immunogen: CHO-derived feline CD134-Fc fusion protein.

Type of Immunogen: Fusion protein

Clone: 7D6

Isotype: IgG1

Application Details

Application Notes: Approved: Flo (1:1 - 1:5), WB

Usage: The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested. Flow Cytometry: Use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL. Method sheets are available on request.

Comment:

Target Species of Antibody: Cat

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS,  pH 7.4, 0.09 % sodium azide, 1 % BSA.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.

Target Details for TNFRSF4

Target: TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))

Alternative Name: TNFRSF4 / CD134 / OX40 (TNFRSF4 Products)

Background: Name/Gene ID: TNFRSF4
Family: TNF Receptor

Synonyms: TNFRSF4, ACT35 antigen, ATC35 antigen, CD134, ACT35, OX40, OX40 antigen, OX40L receptor, OX40 homologue, CD134 antigen, OX40 cell surface antigen, TXGP1L

Gene ID: 7293

Pathways: Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints