GDF15 antibody (N-Term)

Catalog No. ABIN238331

The Mouse Monoclonal anti-GDF15 antibody has been validated for FACS and cELISA. It is suitable to detect GDF15 in samples from Human.

Quick Overview for GDF15 antibody (N-Term) (ABIN238331)

Target: GDF15 (Growth Differentiation Factor 15 (GDF15))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GDF15 antibody is un-conjugated

Application: Flow Cytometry (FACS), Cell-ELISA (cELISA)

Clone: ME-6D10

Product Details anti-GDF15 Antibody

Binding Specificity: AA 30-194, N-Term

Purification: Protein G

Immunogen: genetic immunisation with cDNA encoding aa30-194 (N-term) of MIC-1 proprotein

Isotype: IgG1

Application Details

Application Notes: Flow cytometry: 1.2 µg/10^6 cells
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration.

Comment:

Synonyms: GDF15

Restrictions: For Research Use only

Handling

Buffer: PBS, pH 7.2

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C

Storage Comment: short term: 2 °C - 8 °C, long term: -20 °C

Target Details for GDF15

Target: GDF15 (Growth Differentiation Factor 15 (GDF15))

Alternative Name: MIC-1

Background: Macrophage inhibitory cytokine-1 (MIC-1) is a member of the transforming growth factor-ß superfamily that regulates a wide variety of physiological processes involved in tissue differentiation and maintenance. MIC-1 is synthesized as a 62-kDa intracellular protein, which, after cleavage by a furin like protease, is secreted as a 25-kDa disulphide-linked dimeric protein. Expression of MIC-1 results in inhibition of macrophage activation, regulated by the p53 pathway, in response to pro-inflammatory monokines. MIC-1 is involved in tumour pathogenesis and its measurement can be used as a clinical tool for the diagnosis of a wide range of cancers. It could be a useful marker for aggressive prostate cancer while MIC-1 is upregulated in advanced and more aggressive prostatic tumours.

UniProt: Q99988

Pathways: SARS-CoV-2 Protein Interactome