Linker For Activation of T Cells Family, Member 2 (LAT2) antibody

Antigen: Linker For Activation of T Cells Family, Member 2 (LAT2)

Synonyms: LAB, NTAL, WSCR5, WBSCR5, HSPC046, WBSCR15, LAT2, MGC139435

Clonality: Polyclonal

Host: Rabbit

Reactivity: Mouse (Murine)

Application: Western Blotting (WB)

Catalog no.: ABIN238345

Additional Information

Characteristics: Synonyms: LAB, NTAL, WBS15, WBSCR5, HSPC046, Linker for activation of T-cells family member 2,Non-T-cell activation linker, LLinker for activation of B-cells, Membrane-associated adaptermolecule, Williams-Beuren syndrome chromosomal region 15 protein

Alternative name: LAT2 / WBSCR15

Swiss-Prot: Q9JHL0

Immunogen: Recombinant mouse NTAL (aa 30-203).

Cross-Reactivity: Mouse (Murine), Rat (Rattus)

Description: NTAL (Non-T cell activation linker), also known as LAB (Linker for activation of B cells), is a30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NKcells, mast cells and macrophages. It is a negative regulator of early stages ofBCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partiallyoverlapping with LAT function.

Specificity: The polyclonal antibody reacts with Non-T cell Activation Linker (NTAL), also known as LAB(linker of activated B cells), a 25 kDa transmembrane adaptor protein present in membranemicrodomains (rafts) of B cells, NK cells and myeloid cells. Negative Species: Human. Species: Mouse, Rat. Others not tested.

Application Details

Application Notes: Western Blotting (Non-reducing conditions): Recommended dilution: 1 μg/mlPositive control: mouse spleen. Sample preparation: Mix lysate with non-reducing SDS-PAGE sample buffer. Immunocytochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 1.0 mg/ml

Purification: Aff - Purified

Buffer: PBS, pH 7.4 with 15 mM sodium azide as preservative.

Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Restrictions: For Research Use only