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Antibodies
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anti-P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) antibody
P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) antibody
| Antigen |
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| Synonyms |
CD62, GRMP, PSEL, CD62P, GMP140, LECAM3, PADGEM, FLJ45155, Grmp, MGC129336, MGC129337, P-selectin, PSELECT, MGC124632, SELP |
| Clonality |
Monoclonal (HI62P) |
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Host
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Reactivity
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Human (35), Rat (Rattus) (10), Goat (9), Sheep (Ovine) (9), Monkey (8), Mouse (Murine) (5), Cat (Feline) (4), Cow (Bovine) (4), Horse (Equine) (4), Pig (Porcine) (3), Primate (2), Barley (Hordeum vulgare) (1), Barnyard Grass (Echinochloa crus-galli) (1), Beet (Beta vulgaris) (1), Cotton (Gossypium hirsutum) (1), Fruit Fly (Drosophila melanogaster) (1), Mung bean (Vigna radiata) (1), Sorghum (1), Yeast (Saccharomyces Cerevisiae) (1)
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Application
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| Catalog no. |
ABIN238417 |
| Quantity |
0.1 mg (1.0 mg/ml) |
| Price |
265.00 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 7 to 10 Business Days |
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Characteristics
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Synonyms: SELP, GMRP, GRMP, PADGEM, GMP-140, LECAM3, Granule membrane protein 140,Leukocyte-endothelial cell adhesion molecule 3, CD62 antigen-like family member P
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Alternative name
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CD62P / P-Selectin
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Swiss-Prot
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P16109
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Immunogen
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Human platelets.
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Cross-Reactivity
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Human
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Isotype
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IgG1
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Clone
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HI62P
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Description
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CD62P (P-selectin) is an adhesion glycoprotein that is expressed on platelets andendothelial cells upon their activation. Interaction between CD62P and its mucin-likeligand PSGL-1 (P-selectin glycoprotein ligand-1) expressed on the microvilli of mostleukocytes supports leukocyte rolling along postkapillary venules at the earliest time ofinflammation. Both CD62P and PSGL-1 are extended glycoproteins that form homodimers. CD62P dimerization is probably mediated through interactions of the transmembranedomains and stabilizes leukocyte tethering and rolling, probably by increasing rebindingwithin a bond cluster.
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Specificity
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The antibody HI62P recognizes CD62P (P-selectin), a 140 kD single chain type Itransmembrane glycoprotein present in secretory α-granules in platelets, in Weibel-Paladebodies in endothelial cells and in megakaryocytes, it is relocated to the plasma membraneupon activation. Species: Human. Others not tested.
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Application Notes
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Flow Cytometry. Western Blotting. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
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Concentration
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1.0 mg/ml
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Purification
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Aff - Purified
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Buffer
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PBS, pH 7.4 with 15 mM sodium azide as preservative.
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Storage
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Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
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Restrictions
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For Research Use only
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Alternatives for antigen "P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP)", type "Antibodies"
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Hosts
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Mouse (33), Rabbit (2), Chicken (1)
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Reactivities
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Human (35), Rat (Rattus) (10), Goat (9), Sheep (Ovine) (9), Monkey (8), Mouse (Murine) (5), Cat (Feline) (4), Cow (Bovine) (4), Horse (Equine) (4), Pig (Porcine) (3), Primate (2), Barley (Hordeum vulgare) (1), Barnyard Grass (Echinochloa crus-galli) (1), Beet (Beta vulgaris) (1), Cotton (Gossypium hirsutum) (1), Fruit Fly (Drosophila melanogaster) (1), Mung bean (Vigna radiata) (1), Sorghum (1), Yeast (Saccharomyces Cerevisiae) (1)
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Applications
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Flow Cytometry (FACS) (30), Western Blotting (WB) (16), Immunohistochemistry (Frozen Sections) (IHC (fro)) (10), Immunoprecipitation (IP) (8), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (6), Immunofluorescence (IF) (4), ELISA (Detection) (3), Functional Studies (Func) (2), Immunolocalization (IL) (1)
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Conjugates
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PE (8), FITC (3), APC (1), PE,DY647 (1)
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Alternatives 
