CD105 (Endoglin / TGF-Beta1/3 Receptor) antibody

Details for Product No. ABIN238459
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Antigen
Synonyms END, HHT1, ORW1, AI528660, AI662476, CD105, S-endoglin
Reactivity
Human, Pig (Porcine)
(275), (109), (29), (20), (13), (13), (12), (6), (1)
Host
Mouse
(165), (131), (52), (3), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(45), (35), (23), (11), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
(231), (182), (67), (60), (57), (45), (29), (20), (17), (13), (11), (10), (10), (7), (5), (3), (3), (1), (1), (1)
Pubmed 6 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN238459
308.00 $
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Immunogen Recombinant Vaccinia virus containing the Human CD105 (L-isoform) cDNA.
Clone MEM-229
Isotype IgG2a
Specificity The antibody MEM-229 recognizes CD105 (Endoglin), a 180 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow, it is also present on syncytiotrophoblast on placenta throughout pregnancy.
Cross-Reactivity (Details) Species reactivity (tested):Human, Porcine.
Characteristics Synonyms: ENG, END, HHT1, ORW, ORW1
Purification Protein-A Affinity Chromatography
Alternative Name CD105 / Endoglin
Background CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFβR-2 as a receptor for TGFβ-1 and TGFβ-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFβ-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.Synonyms: END, ENG, HHT1, ORW, ORW1
UniProt P17813
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry: 10 μg/mLPositive Control: Kg1 Human acute myelogenous leukemia cell lineWestern Blotting (Non-Reducing Conditions).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS, pH ~7.4, 15 mM Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-CD105 (Endoglin / TGF-Beta1/3 Receptor) antibody anti-CD105 (Endoglin / TGF-Beta1/3 Receptor) antibody
Background publications Li, Issa, Kumar et al.: "CD105 prevents apoptosis in hypoxic endothelial cells." in: Journal of cell science, Vol. 116, Issue Pt 13, pp. 2677-85, 2003 (PubMed).

Zhu, Sun, Xie et al.: "Hypoxic induction of endoglin via mitogen-activated protein kinases in mouse brain microvascular endothelial cells." in: Stroke; a journal of cerebral circulation, Vol. 34, Issue 10, pp. 2483-8, 2003 (PubMed).

Guo, Slevin, Li et al.: "CD105 inhibits transforming growth factor-beta-Smad3 signalling." in: Anticancer research, Vol. 24, Issue 3a, pp. 1337-45, 2004 (PubMed).

Warrington, Hillarby, Li et al.: "Functional role of CD105 in TGF-beta1 signalling in murine and human endothelial cells." in: Anticancer research, Vol. 25, Issue 3B, pp. 1851-64, 2005 (PubMed).

Piao, Tokunaga: "Significant expression of endoglin (CD105), TGFbeta-1 and TGFbeta R-2 in the atherosclerotic aorta: an immunohistological study." in: Journal of atherosclerosis and thrombosis, Vol. 13, Issue 2, pp. 82-9, 2006 (PubMed).

Plánka, Necas, Srnec et al.: "Use of allogenic stem cells for the prevention of bone bridge formation in miniature pigs." in: Physiological research / Academia Scientiarum Bohemoslovaca, Vol. 58, Issue 6, pp. 885-93, 2010 (PubMed).

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