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HLA-DRB1 antibody

HLA-DRB1 Reactivity: Human WB, FACS, EIA Host: Mouse Monoclonal MEM-267 unconjugated
Catalog No. ABIN238469
  • Target See all HLA-DRB1 Antibodies
    HLA-DRB1 (Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1))
    Reactivity
    • 93
    • 31
    • 11
    • 11
    • 11
    • 11
    • 10
    • 8
    Human
    Host
    • 54
    • 40
    Mouse
    Clonality
    • 53
    • 41
    Monoclonal
    Conjugate
    • 40
    • 9
    • 8
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HLA-DRB1 antibody is un-conjugated
    Application
    • 61
    • 43
    • 39
    • 25
    • 18
    • 18
    • 14
    • 8
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)
    Characteristics
    Synonyms: MHC class II antigen DRB1, DR1, DR-1, HLA class II histocompatibility antigen, DRB1-1 betachain
    Purification
    Protein A affinity chromatography.
    Immunogen
    Purified, insoluble DR1 beta chain (DRB1*0101) expressed in E. coli inclusion bodies.
    Clone
    MEM-267
    Isotype
    IgG2b
    Top Product
    Discover our top product HLA-DRB1 Primary Antibody
  • Application Notes
    Western Blotting. Flow Cytometry: The antibody MEM-267 stains immature dendritic cells that express emptycell surface MHC molecules, but not cells that express predominantly peptide loadedforms. ELISA.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS, pH 7.4 containing 15 mM sodium azide as preservative.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.
    Expiry Date
    12 months
  • Target
    HLA-DRB1 (Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1))
    Alternative Name
    HLA Class II DR beta 1 / HLA-DRB1 (HLA-DRB1 Products)
    Synonyms
    MGC108235 antibody, DRB1 antibody, DRw10 antibody, HLA-DR1B antibody, HLA-DRB antibody, SS1 antibody, major histocompatibility complex, class II, DR beta 1 antibody, hla-drb1 antibody, HLA-DRB1 antibody
    Background
    HLA-DR1 belongs to the HLA class II beta chain paralogues. The MHC Class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. MHC Class II molecules are expressed in antigen presenting cells (APC). The beta chain is approximately 26-28 kDa. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.Synonyms: DR-1, DR1, DRB1-1 beta chain, HLA class II histocompatibility antigen, MHC class II antigen DRB1
    UniProt
    P04229
    Pathways
    TCR Signaling, Positive Regulation of Peptide Hormone Secretion, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, Cancer Immune Checkpoints
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