HLA-DRB1 antibody (PE)

Catalog No. ABIN238470

The PE-conjugated Mouse Monoclonal anti-HLA-DRB1 antibody (Clone MEM-267) (ABIN238470) specifically detects HLA-DRB1 in FACS. The antibody is reactive with Human samples.

Quick Overview for HLA-DRB1 antibody (PE) (ABIN238470)

Target: HLA-DRB1 (Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HLA-DRB1 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Clone: MEM-267

Product Details anti-HLA-DRB1 Antibody (PE)

Characteristics: Synonyms: MHC class II antigen DRB1, DR1, DR-1, HLA class II histocompatibility antigen, DRB1-1 betachain

Purification: Size-Exclusion Chromatography.

Immunogen: Purified, insoluble DR1 beta chain (DRB1*0101) expressed in E. coli inclusion bodies.

Isotype: IgG2b

Application Details

Application Notes: Suitable for Flow Cytometry analysis: 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS containing 15 mM Sodium Azide as preservative and 0.2 % (w/v) high-grade BSA (Protease free) as stabilizer.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody in the dark at 2-8 °C. DO NOT FREEZE! Avoid prolonged exposure to light.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for HLA-DRB1

Target: HLA-DRB1 (Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1))

Alternative Name: HLA Class II DR beta 1 / HLA-DRB1

Background: HLA-DR1 belongs to the HLA class II beta chain paralogues. The MHC Class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. MHC Class II molecules are expressed in antigen presenting cells (APC). The beta chain is approximately 26-28 kDa. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.Synonyms: DR-1, DR1, DRB1-1 beta chain, HLA class II histocompatibility antigen, MHC class II antigen DRB1

UniProt: P04229

Pathways: TCR Signaling, Positive Regulation of Peptide Hormone Secretion, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response