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Transferrin Receptor (p90, CD71) (TFRC) antibody (Biotin)
| Antigen | Transferrin Receptor (p90, CD71) (TFRC) |
| Synonyms | TFR, CD71, TFR1, TRFR, TR, p90, Trfr, Mtvr1, Mtvr-1, AI195355, AI426448, AU015758, 2610028K12Rik, E430033M20Rik, TFRC, tfr, cd71, tfr1, trfr, DKFZp469M0811, LOC100219280 |
| Clonality | Monoclonal (MEM-75) |
| Host |
 Alternatives Mouse |
| Reactivity |
Alternatives Human |
| Conjugate |
Alternatives Biotin |
| Application |
Alternatives Flow Cytometry (FACS)
|
| Catalog no. | ABIN238475 |
| Quantity | 0.1 mg (1.0 mg/ml) |
| Price | 290.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 7 to 10 Business Days |
Additional Information
| Alternative name | CD71 / TFRC |
| Swiss-Prot | P02786 |
| Immunogen | NALM-6 human pre-B cell line |
| Cross-Reactivity | Human |
| Isotype | IgG1 |
| Clone | MEM-75 |
| Description | CD71 (transferrin receptor) is a type II transmembrane glycoprotein expressed as homodimer in erythroid blood cell line and in activated leukocytes. Upon binding of holotransferrin (complex of transferrin and iron ions), CD71 is internalized by clathrin-mediated endocytosis. Acidification of endosomes by vesicular membrane proton pumps leads to dissociation of iron ions, whereas transferrin (apotransferrin) remains associated with CD71 and recycles to the cell surface, where it is released upon exposure to normal pH. CD71 is also involved in uptake of non-transferrin bound iron. Alternate Names: Transferrin Receptor Protein 1, TFRC, TfR1, TfR, TR, Trfr, T9, p90. |
| Specificity | The antibody MEM-75 reacts with CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and lymphocytes, macrophages and erythroid precursors, it is lost on resting blood leukocytes. The antibody MEM-75 does not block binding of transferrin to the receptor. |
Application Details
| Application Notes | This biotinylated antibody is suitable for indirect Immunofluorescence analysis by Flow Cytometry. Suggested working dilution is 1:200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. |
| Concentration | 1.0 mg/ml |
| Buffer | PBS, pH 7.4 containing 15 mM sodium azide as preservative |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch. |
| Research Area | CD Antigens, Surface Receptors of Immune Cells |
| Restrictions | For Research Use only |
Alternatives
Alternatives for antigen "Transferrin Receptor (p90, CD71) (TFRC)", type "Antibodies"
| Hosts | Mouse (100), Rat (25), Rabbit (8), Goat (1) |
| Reactivities | Human (88), Mouse (Murine) (29), Rat (Rattus) (12), Monkey (10) |
| Applications | Flow Cytometry (FACS) (86), Western Blotting (WB) (40), Immunoprecipitation (IP) (32), Immunohistochemistry (Frozen Sections) (IHC (fro)) (28), Enzyme Immunoassay (EIA) (26), ELISA (10), Immunofluorescence (IF) (8), Immunohistochemistry (IHC) (7), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (6), Functional Studies (Func) (4), ELISA (Capture) (3), ELISA (Detection) (3), Immunoelectron Microscopy (EM) (2) |
| Conjugates | Biotin (12), FITC (11), PE (11), APC (2), DY647 (1), SPRD (1) |
| Epitopes | extracellular domain (2), Ab-24 (1), N-Term (1), pSer24 (1) |
