DcR2 antibody (N-Term)

Catalog No. ABIN238513

This Mouse Monoclonal antibody specifically detects DcR2 in FACS. It exhibits reactivity toward Human.

Quick Overview for DcR2 antibody (N-Term) (ABIN238513)

Target: DcR2 (TNFRSF10D) (Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DcR2 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: TRAIL-R4-01

Product Details anti-DcR2 Antibody

Binding Specificity: AA 1-210, N-Term

Specificity: This antibody reacts with TRAIL-R4, a 42 kDa transmembrane protein expressed on various blood cells.

Cross-Reactivity (Details): Species reactivity (tested):Human

Characteristics: Synonyms: TNFRSF10D, DCR2, TRAIL-R4, TRUNDD, Decoy receptor 2, TRAIL receptor 4, Tumor necrosisfactor receptor superfamily member 10D, TNF-related apoptosis-inducing ligand receptor 4,TRAIL receptor with a truncated death domain

Purification: Protein A affinity chromatography

Immunogen: TRAIL-R4 (aa 1-210) - hIgGhc fusion protein.

Isotype: IgG1

Application Details

Application Notes: Suitable for use in Flow Cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4 without preservatives

Preservative: Without preservative

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid freeze/thaw cycles.
Shelf life: One year from despatch.

Expiry Date: 12 months

Target Details for DcR2

Target: DcR2 (TNFRSF10D) (Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D))

Alternative Name: CD264 / TRAILR4

Background: TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4).Synonyms: DCR2, Decoy receptor 2, TNF-related apoptosis-inducing ligand receptor 4, TNFRSF10D, TRAIL receptor 4, TRAIL receptor with a truncated death domain, TRAIL-R4, TRUNDD, Tumor necrosis factor receptor superfamily member 10D

Gene ID: 8793

UniProt: Q9UBN6

Pathways: Apoptosis