SRGAP3 antibody

Catalog No. ABIN2424201

Product Details anti-SRGAP3 Antibody

Target: SRGAP3 (SLIT-ROBO rho GTPase Activating Protein 3 (SRGAP3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRGAP3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Purification: Affinity purification

Immunogen: Recombinant protein of human SRGAP3

Isotype: IgG

Application Details

Application Notes: IHC 1:25-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.6 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Handling Advice: Avoid freeze / thaw cycles.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SRGAP3

Target: SRGAP3 (SLIT-ROBO rho GTPase Activating Protein 3 (SRGAP3))

Alternative Name: SRGAP3 (SRGAP3 Products)

Synonyms: AI452337 antibody, Arhgap14 antibody, D130026O08Rik antibody, Gbi antibody, MEGAP antibody, WRP antibody, mKIAA0411 antibody, RGD1563152 antibody, ARHGAP14 antibody, SRGAP2 antibody, RGD1566016 antibody, srGAP2 antibody, fnbp2 antibody, srgap2 antibody, SLIT-ROBO Rho GTPase activating protein 3 antibody, SLIT-ROBO Rho GTPase activating protein 2 antibody, SLIT-ROBO Rho GTPase activating protein 2 L homeolog antibody, Srgap3 antibody, SRGAP3 antibody, Srgap2 antibody, srgap3 antibody, srgap2.L antibody

Background: SRGAP3 is a 1099 amino acid protein containing 1 FCH domain, 1 Rho-GAP domain and 1 SH3 domain. Expressed highly in brain, and in lower levels in kidney, WRP is thought to play a role in cell migration through its interaction with Cdc42 and Rac1. Cdc42 and Rac1 are two intracellular signaling proteins that regulate the multistep cell migration process. WRP downregulates Cdc42 and Rac1 activity, thereby impairing actin and microtubule dynamics, the formation of protrusions, and total cell migration. Defects in the gene encoding WRP have been linked to severe idiopathic mental retardation. Three isoforms of WRP exist as a result of alternative splicing events.