KDM6A antibody

Catalog No. ABIN2458408

Product Details anti-KDM6A Antibody

Target: KDM6A (Lysine (K)-Specific Demethylase 6A (KDM6A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KDM6A antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human UTX.

Application Details

Application Notes: UTX antibody can be used for detection of UTX by ELISA at 1:312500. UTX antibody can be used for detection of UTX by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store UTX antibody at -20 °C.

Target Details for KDM6A

Target: KDM6A (Lysine (K)-Specific Demethylase 6A (KDM6A))

Alternative Name: UTX (KDM6A Products)

Synonyms: KABUK2 antibody, UTX antibody, bA386N14.2 antibody, Utx antibody, si:ch211-222m21.1 antibody, utx antibody, kdm6a antibody, tutx antibody, uty antibody, xtutx antibody, lysine demethylase 6A antibody, lysine-specific demethylase 6A antibody, lysine (K)-specific demethylase 6A antibody, lysine demethylase 6A S homeolog antibody, KDM6A antibody, LOC100539898 antibody, Kdm6a antibody, kdm6a antibody, kdm6a.S antibody

Background: UTX is a histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. It demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. UTX plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitent with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A.

Molecular Weight: 154 kDa

Gene ID: 7403

NCBI Accession: NP_066963

UniProt: O15550

Pathways: Tube Formation, Warburg Effect