PCDHGC4 antibody

Catalog No. ABIN2459282

Product Details anti-PCDHGC4 Antibody

Target: PCDHGC4 (Protocadherin gamma Subfamily C, 4 (PCDHGC4))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCDHGC4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PCDHGC4.

Application Details

Application Notes: PCDHGC4 antibody can be used for detection of PCDHGC4 by ELISA at 1:1562500. PCDHGC4 antibody can be used for detection of PCDHGC4 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store PCDHGC4 antibody at -20 °C.

Target Details for PCDHGC4

Target: PCDHGC4 (Protocadherin gamma Subfamily C, 4 (PCDHGC4))

Alternative Name: PCDHGC4 (PCDHGC4 Products)

Synonyms: PCDH-GAMMA-C4 antibody, protocadherin gamma c4 antibody, protocadherin gamma subfamily C, 4 antibody, Pcdhgc4 antibody, PCDHGC4 antibody

Background: PCDHGC4 is a single-pass type I membrane protein. It contains 6 cadherin domains.PCDHGC4 is a potential calcium-dependent cell-adhesion protein. It may be involved in the establishment and maintenance of specific neuronal connections in the brain.This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

Molecular Weight: 98 kDa

Gene ID: 56098

NCBI Accession: NP_061751

UniProt: Q9Y5F7