TRIB2 antibody

Catalog No. ABIN2459888

Product Details anti-TRIB2 Antibody

Target: TRIB2 (Tribbles Pseudokinase 2 (TRIB2))

Reactivity: Human, Mouse, Rat, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIB2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TRIB2.

Application Details

Application Notes: TRIB2 antibody can be used for detection of TRIB2 by ELISA at 1:312500. TRIB2 antibody can be used for detection of TRIB2 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store TRIB2 antibody at -20 °C.

Target Details for TRIB2

Target: TRIB2 (Tribbles Pseudokinase 2 (TRIB2))

Alternative Name: TRIB2 (TRIB2 Products)

Synonyms: TRIB2 antibody, Trb2 antibody, Xtrbl antibody, gs3955 antibody, c5fw antibody, trb2 antibody, xtrb2 antibody, TRB2 antibody, C5FW antibody, GS3955 antibody, TRB-2 antibody, AW319517 antibody, RGD1564451 antibody, tribbles pseudokinase 2 antibody, tribbles pseudokinase 2 S homeolog antibody, TRIB2 antibody, trib2 antibody, trib2.S antibody, Trib2 antibody

Background: TRIB2 is one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia.

Molecular Weight: 39 kDa

Gene ID: 28951

NCBI Accession: NP_067675

UniProt: Q92519