SH3BP2 antibody

Catalog No. ABIN2459974

Product Details anti-SH3BP2 Antibody

Target: SH3BP2 (SH3-Domain Binding Protein 2 (SH3BP2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SH3BP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SH3BP2.

Application Details

Application Notes: SH3BP2 antibody can be used for detection of SH3BP2 by ELISA at 1:1562500. SH3BP2 antibody can be used for detection of SH3BP2 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store SH3BP2 antibody at -20 °C.

Target Details for SH3BP2

Target: SH3BP2 (SH3-Domain Binding Protein 2 (SH3BP2))

Alternative Name: SH3BP2 (SH3BP2 Products)

Synonyms: SH3BP2 antibody, 3BP-2 antibody, 3BP2 antibody, CRBM antibody, CRPM antibody, SH3 domain binding protein 2 antibody, SH3-domain binding protein 2 antibody, SH3BP2 antibody, Sh3bp2 antibody

Background: SH3BP2 has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases, and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism.

Molecular Weight: 62 kDa

Gene ID: 6452

NCBI Accession: NP_003014

UniProt: P78314

Pathways: TCR Signaling