PCBP1 antibody
-
- Target See all PCBP1 Antibodies
- PCBP1 (Poly(rC) Binding Protein 1 (PCBP1))
-
Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This PCBP1 antibody is un-conjugated
-
Application
- Western Blotting (WB), ELISA
- Purification
- Antibody is purified by protein A chromatography method.
- Immunogen
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PCBP1.
- Top Product
- Discover our top product PCBP1 Primary Antibody
-
-
- Application Notes
- PCBP1 antibody can be used for detection of PCBP1 by ELISA at 1:62500. PCBP1 antibody can be used for detection of PCBP1 by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.
- Concentration
- 1 mg/mL
- Buffer
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
- Handling Advice
- As with any antibody avoid repeat freeze-thaw cycles.
- Storage
- 4 °C/-20 °C
- Storage Comment
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store PCBP1 antibody at -20 °C.
-
- Target
- PCBP1 (Poly(rC) Binding Protein 1 (PCBP1))
- Alternative Name
- PCBP1 (PCBP1 Products)
- Synonyms
- PCBP1 antibody, HNRPE1 antibody, HNRPX antibody, hnRNP-E1 antibody, hnRNP-X antibody, hnRNP E1 antibody, WBP17 antibody, [a]CP-1 antibody, alphaCP-1 antibody, RGD1561319 antibody, poly(rC) binding protein 1 antibody, poly(rC) binding protein 1 L homeolog antibody, poly(rC)-binding protein 1 antibody, PCBP1 antibody, pcbp1.L antibody, LOC100388387 antibody, Pcbp1 antibody
- Background
- PCBP1 appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly (rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. PCBP1 is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.This intronless gene is thought to be generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly (rC)-binding proteins. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.
- Molecular Weight
- 39 kDa
- Gene ID
- 5093
- NCBI Accession
- NP_006187
- UniProt
- Q15365
-