UGT1A4 antibody

Catalog No. ABIN2463019

Product Details anti-UGT1A4 Antibody

Target: UGT1A4 (UDP Glucuronosyltransferase 1 Family, Polypeptide A4 (UGT1A4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UGT1A4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human UGT1A4.

Application Details

Application Notes: UGT1A4 antibody can be used for detection of UGT1A4 by ELISA at 1:312500. UGT1A4 antibody can be used for detection of UGT1A4 by western blot at 1.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store UGT1A4 antibody at -20 °C.

Target Details for UGT1A4

Target: UGT1A4 (UDP Glucuronosyltransferase 1 Family, Polypeptide A4 (UGT1A4))

Alternative Name: UGT1A4 (UGT1A4 Products)

Synonyms: HUG-BR2 antibody, UDPGT antibody, UDPGT 1-4 antibody, UGT-1D antibody, UGT1-04 antibody, UGT1.4 antibody, UGT1D antibody, UGT1 antibody, UGT1A4 antibody, UDP glucuronosyltransferase family 1 member A4 antibody, UDP-glucuronosyltransferase 1-4 antibody, UGT1A4 antibody, UGT1-4 antibody

Background: UGT1A4 is an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins.This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins.

Molecular Weight: 57 kDa

Gene ID: 54657

NCBI Accession: NP_009051

UniProt: P22310

Pathways: Steroid Hormone Biosynthesis, Regulation of Lipid Metabolism by PPARalpha