ATRX antibody (C-Term)

Catalog No. ABIN2469774

Product Details anti-ATRX Antibody

Target: ATRX (helicase 2, X-linked (ATRX))

Binding Specificity: C-Term

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ATRX antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Protein G Column

Immunogen: ATRX monoclonal antibody was raised against peptides from the C-Terminus of ATRX (Human).

Clone: 60-1

Isotype: IgG

Application Details

Application Notes: ATRX antibody can be used in ELISA, and immunohistochemistry starting at 10 μg/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.2. No preservatives added.

Preservative: Without preservative

Handling Advice: As with all antibodies avoid freeze/thaw cycles.

Storage: -20 °C

Storage Comment: Store ATRX antibody at -20 °C.

Target Details for ATRX

Target: ATRX (helicase 2, X-linked (ATRX))

Alternative Name: ATRX (ATRX Products)

Synonyms: ATR2 antibody, JMS antibody, MRXHF1 antibody, RAD54 antibody, RAD54L antibody, SFM1 antibody, SHS antibody, XH2 antibody, XNP antibody, ZNF-HX antibody, 4833408C14Rik antibody, AI447451 antibody, DXHXS6677E antibody, HP1-BP38 antibody, Hp1bp2 antibody, Hp1bp38 antibody, MRXS3 antibody, Rad54 antibody, Xnp antibody, atrx antibody, rad54 antibody, atrxl antibody, wu:fb26e12 antibody, wu:fb52h08 antibody, wu:fb72g09 antibody, wu:fb94e07 antibody, zgc:66223 antibody, ATRX, chromatin remodeler antibody, alpha thalassemia/mental retardation syndrome X-linked L homeolog antibody, alpha thalassemia/mental retardation syndrome X-linked homolog (human) antibody, ATRX antibody, Atrx antibody, atrx.L antibody, atrx antibody

Background: The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Gene ID: 546

UniProt: P46100