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Integrin beta 2 antibody

ITGB2 Reactivity: Mouse FACS, Func Host: Rat Monoclonal M18-2 unconjugated

Catalog No. ABIN2567290

Datasheet as PDF

Target See all Integrin beta 2 (ITGB2) Antibodies

Integrin beta 2 (ITGB2)
Reactivity
192

53

43

9

6

3

3

2

2

2

2

2

2

2

1

1
Mouse
Host
99

88

35

2

1

1
Rat
Compatible Secondaries
Clonality
132

89

2
Monoclonal
Conjugate
101

22

20

16

8

5

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1
This Integrin beta 2 antibody is un-conjugated
Application
130

82

52

44

37

32

28

26

26

25

22

12

8

3

3

3

2

2

1

1
Flow Cytometry (FACS), Functional Studies (Func)

Specificity

The M18/2 monoclonal antibody specifically binds to mouse CD18, a 95kDA integrin beta 2 glycoprotein.

Purification

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/μg of the protein.

Clone

M18-2

Isotype

IgG2a kappa

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anti-Integrin beta 2 (ITGB2) antibody
ITGB2 Reactivity: Human FACS, WB, IP, IHC (fro), Func, IHC (p) Host: Mouse Monoclonal MEM-48 unconjugated

anti-Integrin beta 2 (ITGB2) antibody
ITGB2 Reactivity: Human FACS, WB, IP, IHC (fro), IHC (p) Host: Mouse Monoclonal MEM-48 unconjugated

anti-Integrin beta 2 (ITGB2) antibody (FITC)
ITGB2 Reactivity: Human FACS Host: Mouse Monoclonal MEM-48 FITC

anti-Integrin beta 2 (ITGB2) antibody (Biotin)
ITGB2 Reactivity: Human FACS, WB, IP, IHC (fro), IHC (p) Host: Mouse Monoclonal MEM-48 Biotin

anti-Integrin beta 2 (ITGB2) antibody (PE)
ITGB2 Reactivity: Human FACS Host: Mouse Monoclonal MEM-48 PE

anti-Integrin beta 2 (ITGB2) (AA 70-170) antibody
ITGB2 Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated

anti-Integrin beta 2 (ITGB2) antibody
ITGB2 Reactivity: Mouse FACS, WB, IP, IHC (fro), Func, IHC (p) Host: Rat Monoclonal M18-2 unconjugated

anti-Integrin beta 2 (ITGB2) (AA 559-700) antibody
ITGB2 Reactivity: Human FACS, WB, ELISA Host: Mouse Monoclonal 3C11G5 unconjugated

anti-Integrin beta 2 (ITGB2) (AA 17-382) antibody
ITGB2 Reactivity: Human, Mouse, Rat WB, IHC (p) Host: Rabbit Polyclonal unconjugated

anti-Integrin beta 2 (ITGB2) antibody
ITGB2 Reactivity: Mouse FACS, WB, IP, IHC (fro), IHC (p) Host: Rat Monoclonal M18-2 unconjugated

Application Notes

Optimal working dilution should be determined by the investigator.

Restrictions

For Research Use only
Format

Liquid

Concentration

1 mg/mL

Buffer

Phosphate-buffered aqueous solution, ph7.2.

Storage

4 °C

Storage Comment

The product should be stored undiluted at 4°C. Do not freeze.
Target

Integrin beta 2 (ITGB2)

Alternative Name

CD18 (ITGB2 Products)

Background

The M18/2 monoclonal antibody specifically binds to mouse CD18, a 95kDA integrin beta 2 glycoprotein. CD18 is expressed on all leukocytes with the highest density by NK and T cells. CD18 forms LFA-1 with CD11a, Mac-1 with CD11b and gp150/95 with CD11c. Through these interactions, CD18 has an important role in cellular adhesion. The M18/2 antibody is reported to stimulate Mac-1 and LFA-1 adhesion to their ligands and block tumor cell metastasis.

Gene ID

16414

UniProt

P11835

Pathways

NF-kappaB Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation