CYP2A6 antibody (C-Term, pSer472)

Catalog No. ABIN264498

Product Details anti-CYP2A6 Antibody

Target: CYP2A6 (Cytochrome P450, Family 2, Subfamily A, Polypeptide 6 (CYP2A6))

Binding Specificity: C-Term, pSer472

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CYP2A6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to Cytochrome p450 2A6.

Characteristics: Synonyms: CYP2A3, Cytochrome P450 2A6, CYPIIA6, CYPIIA3, Coumarin 7-hydroxylase

Purification: Purified

Immunogen: Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized withSynthetic peptide conjugated to ovalbumin derived from the C-terminus of CYP2A6 andmouse myeloma Ag8563 cells. Antigen identical in CYP2A6, 2A7 and 2A13.

Clone: F16 P2 D8

Isotype: IgG1

Application Details

Application Notes: ELISA. Immunohistochemistry on paraffin sections. Western Blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CYP2A6

Target: CYP2A6 (Cytochrome P450, Family 2, Subfamily A, Polypeptide 6 (CYP2A6))

Alternative Name: CYP2A6 (CYP2A6 Products)

Synonyms: CPA6 antibody, CYP2A antibody, CYP2A3 antibody, CYPIIA6 antibody, P450C2A antibody, P450PB antibody, cyp2a6 antibody, cytochrome P450 family 2 subfamily A member 6 antibody, cytochrome P450 2A6 antibody, cytochrome P450 family 2 subfamily A member 6 L homeolog antibody, CYP2A6 antibody, cyp2a6.L antibody

Background: The cytochrome P450 proteins (CYPs) are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. P450 enzymes are classified into subfamilies based on their sequence similarities. CYP2A6 is a liver enzyme that metabolizes a number of drugs and a variety of procarcinogens, though it is primarily responsible for the metabolism of nicotine, the major addictive agent in tobacco. CYP2A6 inactivates nicotine to cotinine, and then cotinine to 3-hydroxycotinine. Differences in CYP2A6 genotypes are related to nicotine dependence, and may influence smoking habits and withdrawal symptoms in individuals that are quitting smoking. This suggests that an individualized smoking cessation program may be designed based on CYP2A6 genotypes.Synonyms: CYP2A3, CYPIIA3, CYPIIA6, Coumarin 7-hydroxylase, Cytochrome P450 2A6

Gene ID: 1548

UniProt: P11509