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Antibodies
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anti-1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (Lysophosphatidic Acid Acyltra...
1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (Lysophosphatidic Acid Acyltransferase, Beta) (AGPAT2) antibody
| Antigen |
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| Synonyms |
BSCL, BSCL1, LPAAB, 1-AGPAT2, LPAAT-beta, AV000834, 2510002J07Rik, AGPAT2, MGC138073, zgc:153984 |
| Clonality |
Polyclonal |
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Host
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Reactivity
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Application
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 Alternatives Enzyme Immunoassay (EIA), Western Blotting (WB)
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| Catalog no. |
ABIN265083 |
| Quantity |
100 µg (Lot specific) |
| Price |
430.00 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 7 to 10 Business Days |
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Characteristics
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Synonyms: 1-AGP acyltransferase 2, LPAAT-beta, 1-acyl-sn-glycerol-3-phosphate acyltransferase beta,Lysophosphatidic acid acyltransferase beta, 1-acylglycerol-3-phosphate O-acyltransferase2
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Alternative name
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AGPAT2
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Swiss-Prot
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O15120
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Immunogen
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Synthetic peptide derived from the LPAAT-beta protein.
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Cross-Reactivity
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Human
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Isotype
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IgG (Matching secondary antibodies)
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Description
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Lysophospholipid Acyltransferases (LPLATs) catalyse the addition of fatty acyl moieties tothe glycerol backbone of lysophospholipids . In addition to playing a crutial role in thesynthesis of structural membrane components the LPLATs are also implicated in cellularsignalling responses for cytokines, growth factors and other agonists. Cellular signallingthrough the interleukin 1 receptor in human mesangial cells and EL-4 cells proceeds by theactivation of lysophosphatidic acid acyltransferase (LPAAT). Activation of LPAAT byinterleukin 1 results in the generation of unsaturated phosphatidic acid species, that arecrucial to the generation of diacylglycerol and interleukin 1 signalling. LPLATs are alsoinvolved in signalling for increased interleukin 2 synthesis through the T cell antigenreceptor. Activation of T-cells via anti-CD3 stimulation has been shown to increaseincorporation of polyunsaturated fatty acids into phosphatidylcholine vialysophosphatidylcholine acyltransferase. Activation of this enzyme is essential for thesustained activation and translocation of protein kinase C.
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Specificity
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This antibody detects Lysophosphatidic Acid Acetyltransferase beta. Species: Human. Others not tested.
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Application Notes
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Western Blot: 5-10 µg/ml. Enzyme Immunoassay. Positive Control: Human Brain Lysate. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
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Concentration
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Lot specific
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Purification
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Purified
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Buffer
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Phosphate buffered saline with 0.08% Sodium Azide as preservative.
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Storage
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Ship on dry ice. Store (in aliquots) at -20°C only. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
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Restrictions
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For Research Use only
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Alternatives for antigen "1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (Lysophosphatidic Acid Acyltransferase, Beta) (AGPAT2)", type "Antibodies"
