Sphingomyelin Synthase 1 antibody

Catalog No. ABIN265114

This Rabbit Polyclonal antibody specifically detects Sphingomyelin Synthase 1 in WB and EIA. It exhibits reactivity toward Human and Mouse.

Quick Overview for Sphingomyelin Synthase 1 antibody (ABIN265114)

Target: Sphingomyelin Synthase 1 (SGMS1)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Sphingomyelin Synthase 1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-Sphingomyelin Synthase 1 Antibody

Specificity: This antibody reacts to Sphingomyelin Synthase 1.

Purification: Purified

Immunogen: Synthetic peptide derived from the mouse sphingomyelin synthase 1 protein

Application Details

Application Notes: ELISA. Western Blot: 5 - 10 μg/mL. Positive Control: Brain, heart, kidney, liver, muscle and stomach.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline, pH 7.4

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Target Details for Sphingomyelin Synthase 1

Target: Sphingomyelin Synthase 1 (SGMS1)

Alternative Name: TMEM23 / SGMS1

Background: A bidirectional lipid cholinephosphotransferases capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and the inverse reaction. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. May not function strictly as a SM synthase. Inhibited by bacterial PC-phospholipase C inhibitor D609. Localized to Golgi apparatus, Golgi membrane, multi-pass membrane protein. Possibly present on Brain, heart, kidney, liver, muscle and stomach.Synonyms: MOB, Medulla oblongata-derived protein, Phosphatidylcholine:ceramide cholinephosphotransferase 1, SMS1, Sphingomyelin synthase 1, Transmembrane protein 23

Gene ID: 259230

NCBI Accession: NP_671512

UniProt: Q86VZ5

Pathways: Cellular Response to Molecule of Bacterial Origin