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Sphingomyelin Synthase 1 antibody (Middle Region)

SGMS1 Reactivity: Human, Mouse, Rat, Horse, Rabbit, Cow, Dog, Guinea Pig, Zebrafish (Danio rerio) WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2786225
  • Target See all Sphingomyelin Synthase 1 (SGMS1) Antibodies
    Sphingomyelin Synthase 1 (SGMS1)
    Binding Specificity
    • 15
    • 8
    • 8
    • 6
    • 5
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 27
    • 20
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Human, Mouse, Rat, Horse, Rabbit, Cow, Dog, Guinea Pig, Zebrafish (Danio rerio)
    Host
    • 42
    Rabbit
    Clonality
    • 42
    Polyclonal
    Conjugate
    • 14
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Sphingomyelin Synthase 1 antibody is un-conjugated
    Application
    • 38
    • 20
    • 15
    • 13
    • 13
    • 5
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    LTTVMISVVH ERVPPKEVQP PLPDTFFDHF NRVQWAFSIC EINGMILVGL
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 77%
    Characteristics
    This is a rabbit polyclonal antibody against Sgms1. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of Mouse Sgms1
    Top Product
    Discover our top product SGMS1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 419 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Miyamoto, Hsu, Hamm, Darshi, Diamond-Stanic, Declèves, Slater, Pennathur, Stauber, Dorrestein, Sharma: "Mass Spectrometry Imaging Reveals Elevated Glomerular ATP/AMP in Diabetes/obesity and Identifies Sphingomyelin as a Possible Mediator." in: EBioMedicine, Vol. 7, pp. 121-34, (2016) (PubMed).

  • Target
    Sphingomyelin Synthase 1 (SGMS1)
    Alternative Name
    Sgms1 (SGMS1 Products)
    Synonyms
    MGC81436 antibody, TMEM23 antibody, MOB antibody, MOB1 antibody, SMS1 antibody, hmob33 antibody, 9530058O11Rik antibody, AI841905 antibody, C80702 antibody, Mob antibody, Sms1 antibody, Sor1 antibody, Tmem23 antibody, sphingomyelin synthase 1 antibody, sphingomyelin synthase 1 S homeolog antibody, phosphatidylcholine:ceramide cholinephosphotransferase 1 antibody, SGMS1 antibody, sgms1.S antibody, LOC100013212 antibody, Sgms1 antibody
    Background
    Bidirectional lipid cholinephosphotransferase is capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Sgms1 directly and specifically recognizes the choline head group on the substrate. It also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Sgms1 does not function strictly as a SM synthase and suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. Sgms1 may protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.
    Alias Symbols: 9530058O11Rik, AI841905, C80702, MGC30540, Mob, Sms1, Sor1, Tmem23
    Protein Size: 419
    Molecular Weight
    46 kDa
    Gene ID
    208449
    NCBI Accession
    NM_144792, NP_659041
    UniProt
    Q8VCQ6
    Pathways
    Cellular Response to Molecule of Bacterial Origin
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