PPAPDC2 antibody

Catalog No. ABIN265121

Product Details anti-PPAPDC2 Antibody

Target: PPAPDC2 (Phosphatidic Acid Phosphatase Type 2 Domain Containing 2 (PPAPDC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPAPDC2 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody reacts to Phosphatidic Acid Phosphatase Domain Containing 2 (PPAPDC2).

Purification: Affinity Purified

Immunogen: Synthetic peptide derived from human phosphatidic acid phosphatase type 2 domain containing 2 (PPAPDC2)

Application Details

Application Notes: Western Blot: 1: 400 - 1: 800. Positive Control: Testis.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Ship on gel ice. Store (in aliquots) at -20 °C only.

Target Details for PPAPDC2

Target: PPAPDC2 (Phosphatidic Acid Phosphatase Type 2 Domain Containing 2 (PPAPDC2))

Alternative Name: PPAPDC2 (PPAPDC2 Products)

Synonyms: PPAPDC2 antibody, PDP1 antibody, PSDP antibody, bA6J24.6 antibody, 4932443D16Rik antibody, phospholipid phosphatase 6 antibody, PLPP6 antibody, plpp6 antibody, Plpp6 antibody

Background: Upon cell activation Presqualene diphosphate (PSDP)2, a bioactive lipid, rapidly remodels to presqualene monophosphate (PSMP). A newly identified and characterized phosphatase (phosphatidic acid phosphatase domain containing 2 (PPAPDC2)) has recent,y been shown to convert PSDP to PSMP. Unlike the related polyisoprenyl phosphate farnesyl diphosphate (FDP), PSDP has been shown not to be a substrate for type 2 lipid phosphate phosphohydrolases. PSDP phosphatase activity has been identified in activated human neutrophil (PMN) extracts. Recombinant PPAPDC2 displays diphosphate phosphatase activity with substrate preference for PSDP > FDP phosphatidic acid. PPAPDC2 activity is independent of Mg2+ and optimal at pH 7.0 - 8.0. PPAPDC2 mRNA has been detected in human PMN, and is widely expressed in human tissues. PPAPDC2 expressed in human PMN is first lipid phosphate phosphohydrolase identified for PSDP. The regulation of this enzymes activity has important implications for PMN activation in innate immunity.Synonyms: PPAP2 domain-containing protein 2, Phosphatidic acid phosphatase type 2 domain-containing protein 2, Presqualene diphosphate phosphatase

Gene ID: 403313

NCBI Accession: NP_982278

UniProt: Q8IY26