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Details for Product No. ABIN265158

Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1) (C-Term) antibody

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Antigen
Synonyms CIR1, UEV1, CROC1, UBE2V, UEV-1, UEV1A, CROC-1, 0610011J09Rik, AI256840, D7Bwg1382e, CROC-1B, TMEM189-UBE2V1, UBE2V1, UBE2V2
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 6 references available
Catalog no. ABIN265158
Quantity 0.1 mg
Price
357.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Peptide corresponding to 15 amino acids near the C-terminus of human UEV1A
Isotype IgG
Specificity This antibody detetcs UEV1A. UE1A is one of seven named isoforms of UEV1. UEV1A is located in the nucleus, while iosforms 3 and 5 are found in the membrane (7). This antibody may also recognize other isoforms of UEV1A.
Purification Purified
Alternative Name UBE2V1 / CROC1
Background Ubiquitin-conjugating enzyme E2 (UEV1) was initially discovered as a protein similar in sequence and structure to the E2 ubiquitin-conjugating enzymes but lacking their enzymatic activity (1). There are at least two variants and multiple isoforms of UEV1. In particular, UEV1A (Ubiquitin-conjugating enzyme E2 variant 1 isoform A) has recently been shown to be an important component of the Toll-like receptor and IL-1R signaling pathway (reviewed in 2). Signals from these pathways are relayed by a number of downstream molecules such as MyD88 and tumor necrosis factor receptor associated factor (TRAF6), ultimately activating various kinases and transcription factors (2,3). UEV1A is part of a dimeric ubiquitin-conjugating enzyme complex also containing Ubc13 (ubiquitin- conjugating enzyme 13) that together with TRAF6 activates TAK1, a member of the mitogen- activated protein kinase kinase kinase family (4-6). The Ubc13-UEV1A complex also mediates the Lys-63 ubiquitination of TRAF-6, and this ubiquitination is essential for TAK1 activation (5).
Alternate names: CROC-1, P/OKcl.19, TRAF6-regulated IKK activator 1 beta Uev1A, UBE2V, UEV-1, UEV1, Ubiquitin-conjugating enzyme E2 variant 1
Gene ID 387522
NCBI Accession NP_001027459.1
UniProt Q13404
Application Notes Western Blot: 1 to 2 ug/ml. Postive Control: Jurkat Cell Lysate. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer Phosphate buffered saline with 0.02% sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
Expiry Date 12 months
Background publications Yamaguchi, Shirakabe, Shibuya et al.: "Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction." in: Science (New York, N.Y.), Vol. 270, Issue 5244, pp. 2008-11, 1996 (PubMed).

Sancho, Vilá, Sánchez-Pulido et al.: "Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells." in: Molecular and cellular biology, Vol. 18, Issue 1, pp. 576-89, 1998 (PubMed).

Deng, Wang, Spencer et al.: "Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain." in: Cell, Vol. 103, Issue 2, pp. 351-61, 2000 (PubMed).

Wang, Deng, Hong et al.: "TAK1 is a ubiquitin-dependent kinase of MKK and IKK." in: Nature, Vol. 412, Issue 6844, pp. 346-51, 2001 (PubMed).

Vogel, Fitzgerald, Fenton: "TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression." in: Molecular interventions, Vol. 3, Issue 8, pp. 466-77, 2004 (PubMed).

Akira, Takeda: "Toll-like receptor signalling." in: Nature reviews. Immunology, Vol. 4, Issue 7, pp. 499-511, 2004 (PubMed).

Alternatives for antigen "Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1)", type "Antibodies"
Hosts (50), (5), (4)
Reactivities (58), (24), (22), (11), (11)
Applications (46), (21), (9), (8), (4), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (15), (4), (3), (2), (2), (2), (1), (1), (1), (1)
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