Adiponectin, C1Q and Collagen Domain Containing (ADIPOQ) (N-Term) antibody

Details for Product No. ABIN265161
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Antigen
Synonyms ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, APM1, GBP28, APN, Acdc, apM1, 30kDa, adipo, Acrp30, ADN, MGC84292, ADIPOQ
Epitope
N-Term
(19), (17), (8), (5), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(278), (100), (74), (20), (16), (16), (15), (4), (4)
Host
Rabbit
(198), (141), (8), (6), (4), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(30), (9), (4), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
(254), (218), (43), (41), (38), (26), (25), (19), (13), (10), (9), (7), (4), (4), (4), (4), (3), (1), (1), (1)
Pubmed 5 references available
Catalog no. ABIN265161
Quantity 0.1 mg
Price
368.50 $   Plus shipping costs $45.00
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  • +1 888 205 9894 (TF)
Immunogen A 15 amino acid peptide from near the amino terminus of human adiponectin
Isotype IgG
Specificity This antibody detects Adiponectin.
Purification Affinity chromatography
Alternative Name Adiponectin
Background Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines (reviewed in 1). One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-?-related proteins (CTRPs) 1-7 (2). Unlike the CTRPs, which are expressed in a wide variety of tissues, adiponectin is reported to be expressed exclusively by differentiated adipocytes (3). These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene (4). It is present in high levels in normal human plasma, but is reduced in obese subjects and often in those with increased insulin resistance and type 2 diabetes, suggesting that adiponectin may be a useful pharmacological target in various metabolic diseases (5). Adiponectin a secreted protein synthesized exclusively by adipocytes (6).
Alternate names: 30 kDa adipocyte complement-related protein, ACDC, ACRP30, ADIPOQ, APM1, Adipocyte, Adipocyte complement-related 30 kDa protein, Adipose most abundant gene transcript 1 protein, C1q and collagen domain-containing protein, GBP28, Gelatin-binding protein
Gene ID 9370
NCBI Accession NP_001171271.1
UniProt Q15848
Research Area Cancer, Atherosclerosis, Metabolism, Hormones
Application Notes Western Blot: 1 ug/ml. Positive Control: Rat brain cell lysate. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer Phosphate buffered saline with 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
Expiry Date 12 months
Supplier Images
anti-Adiponectin, C1Q and Collagen Domain Containing (ADIPOQ) (N-Term) antibody anti-Adiponectin, C1Q and Collagen Domain Containing (ADIPOQ) (N-Term) antibody
Background publications Shapiro, Scherer: "The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor." in: Current biology : CB, Vol. 8, Issue 6, pp. 335-8, 1998 (PubMed).

Tsao, Lodish, Fruebis: "ACRP30, a new hormone controlling fat and glucose metabolism." in: European journal of pharmacology, Vol. 440, Issue 2-3, pp. 213-21, 2002 (PubMed).

Wong, Wang, Hug et al.: "A family of Acrp30/adiponectin structural and functional paralogs." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 28, pp. 10302-7, 2004 (PubMed).

Lihn, Pedersen, Richelsen: "Adiponectin: action, regulation and association to insulin sensitivity." in: Obesity reviews : an official journal of the International Association for the Study of Obesity, Vol. 6, Issue 1, pp. 13-21, 2005 (PubMed).

Fantuzzi: "Adipose tissue, adipokines, and inflammation." in: The Journal of allergy and clinical immunology, Vol. 115, Issue 5, pp. 911-9; quiz 920, 2005 (PubMed).

Hosts (198), (141), (8), (6), (4), (1)
Reactivities (278), (100), (74), (20), (16), (16), (15), (4), (4)
Applications (254), (218), (43), (41), (38), (26), (25), (19), (13), (10), (9), (7), (4), (4), (4), (4), (3), (1), (1), (1)
Conjugates (30), (9), (4), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (19), (17), (8), (5), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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