-
- Target See all CHEK2 Antibodies
- CHEK2 (Checkpoint Kinase 2 (CHEK2))
-
Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This CHEK2 antibody is un-conjugated
-
Application
- Western Blotting (WB), ELISA
- Specificity
- Chk2 (Q510) antibody detects endogenous levels of Chk2 protein. Species: Human. Others not tested.
- Characteristics
- Synonyms: CHEK2, CHEK-2, CHK-2, RAD53, Cds1, Serine/threonine-protein kinase Chk2, CHK2checkpoint homolog
- Purification
- Aff - Purified
- Top Product
- Discover our top product CHEK2 Primary Antibody
-
anti-Checkpoint Kinase 2 (CHEK2) (pThr387) antibody
CHEK2 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (pSer516) antibodyCHEK2 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (pThr68) antibodyCHEK2 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (pThr383) antibodyCHEK2 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (AA 111-141), (N-Term) antibodyCHEK2 Reactivity: Human WB, IF, IHC (p), FACS Host: Rabbit Polyclonal RB19067 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (AA 1-543) antibodyCHEK2 Reactivity: Human WB, IP Host: Rabbit Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (AA 1-543) antibodyCHEK2 Reactivity: Human WB, ELISA, IF, IHC (p) Host: Mouse Monoclonal 4B7 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) antibodyCHEK2 Reactivity: Human, Monkey, Dog WB, IHC, IF, IHC (p), FACS Host: Mouse Monoclonal 10G7 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) antibodyCHEK2 Reactivity: Human, Dog WB, IHC, IF, IHC (p), IP, FACS Host: Mouse Monoclonal 5C4 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) antibodyCHEK2 Reactivity: Human, Dog WB, IHC, IHC (p), IP, FACS Host: Mouse Monoclonal 2H5 unconjugated
-
- Application Notes
- ELISA: 1: 20000~1: 40000. WB: 1: 500~1: 1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
- Restrictions
- For Research Use only
-
- Storage
- 4 °C
- Storage Comment
- Store the antibody undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.
- Expiry Date
- 12 months
-
- Target
- CHEK2 (Checkpoint Kinase 2 (CHEK2))
- Alternative Name
- CHK2 (CHEK2 Products)
- Synonyms
- CDS1 antibody, CHK2 antibody, HuCds1 antibody, LFS2 antibody, PP1425 antibody, RAD53 antibody, hCds1 antibody, fa66f08 antibody, wu:fa66f08 antibody, zgc:55865 antibody, Cds1 antibody, HUCDS1 antibody, Rad53 antibody, Chk2 antibody, cds1 antibody, chek2 antibody, chk2 antibody, hucds1 antibody, lfs2 antibody, pp1425 antibody, rad53 antibody, checkpoint kinase 2 antibody, serine/threonine-protein kinase chk2 antibody, checkpoint kinase 2 L homeolog antibody, CHEK2 antibody, chek2 antibody, Chek2 antibody, MCYG_07308 antibody, chek2.L antibody
- Background
- Cell cycle events are regulated by the sequential activation and deactivation of cyclindependent kinases (Cdks) and by proteolysis of cyclins. Chk1 and Chk2 are involved inthese processes as regulators of Cdks. Chk1 and Chk2 both function as essentialcomponents in the G2 DNA damage checkpoint by phosphorylating Cdc25C in response toDNA damage. Phosphorylation inhibits Cdc25C activity, thereby blocking mitosis. Cdc25A,Cdc25B and Cdc25C protein tyrosine phosphatases function as mitotic activators bydephosphorylating Cdc2 p34 on regulatory tyrosine residues. It has also been shown thatChk1 can phosphorylate Wee1 in vitro, providing evidence that the hyperphosphorylatedform of Wee1, seen in cells delayed by Chk1 overexpression, is due to phosphorylation byChk1.
- UniProt
- O96017
- Pathways
- p53 Signaling, Apoptosis, Cell Division Cycle
-
You are here:
