Interleukin 22 (IL22) (AA 34-179) antibody (Alexa Fluor 647)

Details for Product No. ABIN2657957, Supplier: Log in to see
Antigen
  • IL-17D
  • IL-22
  • IL-27
  • IL27
  • IL-21
  • IL-D110
  • IL-TIF
  • ILTIF
  • TIFIL-23
  • TIFa
  • zcyto18
  • IL-22a
  • ILTIFa
  • Iltif
  • RGD1561292
  • interleukin-22
  • interleukin 22
  • interleukin 17D
  • il22
  • IL17D
  • IL22
  • Il22
  • LOC100348980
  • IL-22
Epitope
AA 34-179
61
13
12
9
8
5
3
3
3
3
2
1
1
1
1
1
Reactivity
Mouse (Murine)
228
132
35
2
2
2
2
1
1
1
1
1
Host
Goat
133
112
62
13
Clonality (Clone)
Polyclonal ()
Conjugate
Alexa Fluor 647
32
21
14
10
10
10
10
9
9
7
6
6
6
6
6
6
6
6
4
4
4
4
3
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
222
93
80
31
20
13
11
8
6
5
3
3
3
2
2
2
Options
Supplier
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Supplier Product No.
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Immunogen AA 34-179 (Accession# NM_016971), was expressed in E. coli.
Clone Poly5164
Isotype IgG
Purification The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 647 under optimal conditions.
Alternative Name IL-22 (IL22 Antibody Abstract)
Background IL-22 is a cytokine structurally related to IL-10. Mouse IL-22 consists of 179 amino acids and has a predicted molecular weight of 20 kD. It is secreted primarily by Th17, Th1, Th2, lymphoid tissue inducer cells (LTi), and subsets of natural killer cells. It has been reported that aryl hydrocarbon receptor (AhR) expression is essential for the production of IL-22 by TCRγδ T cells. AhR activation increases Th17 polarization and induces IL-22 production. IL-22 functions by engaging the heterodimeric IL-22 receptor (IL-22R) complex, consisting of two receptor subunits, IL-22R1 and IL-10Rβ. IL-22 acts on nonhematopoietic tissue cells, such as epithelial cells of the digestive and respiratory systems and keratinocytes of the skin. IL-22 is involved in inflammatory processes such as dermal inflammation, psoriasis, inflammatory bowel disease, hepatitis, and Crohn's disease. Moreover, it plays a critical role in mucosal immunity and the wound healing process.
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C
Supplier Images
Flow Cytometry (FACS) image for anti-Interleukin 22 (IL22) (AA 34-179) antibody (Alexa Fluor 647) (ABIN2657957) anti-Interleukin 22 (IL22) (AA 34-179) antibody (Alexa Fluor 647)
Background publications Martin, Hirota, Cua, Stockinger, Veldhoen: "Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals." in: Immunity, Vol. 31, Issue 2, pp. 321-30, 2009 (PubMed).

Veldhoen, Hirota, Christensen, OGarra, Stockinger: "Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells." in: The Journal of experimental medicine, Vol. 206, Issue 1, pp. 43-9, 2009 (PubMed).

Wolk, Witte, Hoffmann, Doecke, Endesfelder, Asadullah, Sterry, Volk, Wittig, Sabat: "IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 9, pp. 5973-81, 2007 (PubMed).

Zheng, Danilenko, Valdez, Kasman, Eastham-Anderson, Wu, Ouyang: "Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis." in: Nature, Vol. 445, Issue 7128, pp. 648-51, 2007 (PubMed).

Liang, Tan, Luxenberg, Karim, Dunussi-Joannopoulos, Collins, Fouser: "Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides." in: The Journal of experimental medicine, Vol. 203, Issue 10, pp. 2271-9, 2006 (PubMed).

Dumoutier, Louahed, Renauld: "Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 4, pp. 1814-9, 2000 (PubMed).

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