CLEC10A antibody

Catalog No. ABIN2664536

Product Details anti-CLEC10A Antibody

Target: CLEC10A (C-Type Lectin Domain Family 10, Member A (CLEC10A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CLEC10A antibody is un-conjugated

Application: ELISA (Capture)

Purification: The antibody was purified by affinity chromatography.

Clone: H037G3

Isotype: IgG2a kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for CLEC10A

Target: CLEC10A (C-Type Lectin Domain Family 10, Member A (CLEC10A))

Alternative Name: CD301 (CLEC10A Products)

Synonyms: CLEC10A antibody, CD301 antibody, CLECSF13 antibody, CLECSF14 antibody, HML antibody, HML2 antibody, MGL antibody, CD301a antibody, M-ASGP-BP-1 antibody, Mgl antibody, Mgl1 antibody, Mgll antibody, C-type lectin domain family 10 member A antibody, C-type lectin domain containing 10A antibody, C-type lectin domain family 10, member A antibody, LOC607405 antibody, CLEC10A antibody, Clec10a antibody

Background: CD301, also known as CLEC10A, macrophage galactose/N-acetylgalactosamine (GalNAc) specific lectin (MGL), DCASGPR, and HML, is a 40 kD type II transmembrane glycoprotein, which belongs to the C-type lectin family. Human CD301 consists of a 39 amino acid (aa) cytoplasmic region, a 21 aa transmembrane segment, and a 256 aa extracellular domain (ECD) with one carbohydrate recognition domain (CRD) and a neck region. CD301 is expressed on immature myleloid dendritic cells and alternatively activated (tolerogenic) macrophages. The expression level is upregulated by immunosuppressant dexamethasone. Human CD301 has an exclusive specificity for rare terminal GalNAc structures, which are revealed on the tumor-associated mucin MUC1 and CD45 (RA, RB, and RC but not RO isoforms). This interaction inhibits effector T cell activation and induces their apoptosis. CD301 also binds the GP envelope glycoprotein on Marburg and Ebola viruses and enhances viral entry and infectivity.