DDX1 antibody

Catalog No. ABIN2664923

Product Details anti-DDX1 Antibody

Target: DDX1 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 1 (DDX1))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This DDX1 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography.

Clone: 9F12B04

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for DDX1

Target: DDX1 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 1 (DDX1))

Alternative Name: DDX1 (DDX1 Products)

Synonyms: CG9054 antibody, DDX1 antibody, Dbp79E antibody, DmDDX1 antibody, DmRH12 antibody, Dmel\\CG9054 antibody, anon-79E antibody, DBP-RB antibody, UKVH5d antibody, si:ch211-214k9.2 antibody, si:dkey-161f12.1 antibody, AA409185 antibody, Dead-box-1 antibody, DEAD-box helicase 1 antibody, DEAD/H-box helicase 1 L homeolog antibody, DEAD (Asp-Glu-Ala-Asp) box helicase 1 antibody, DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 antibody, Ddx1 antibody, DDX1 antibody, ddx1.L antibody, ddx1 antibody

Background: DDX1, also known as DEAD box protein retinoblastoma, is a member of the DEAD (Asp-Glu-Ala-Asp)-box RNA helicase family. DDX1 possesses RNA nuclease, binding, unwinding, and ATPase activities, and is thus involved in RNA metabolism, pre-mRNA splicing, translation initiation, and ribosome biogenesis. DDX1 interacts with the Rev protein of HIV-1 and has been shown to be crucial in the viral RNA replication. DDX1 was found to locate to the area of DNA damage induced by ionizing radiation and is implicated to participate in double-strand DNA break repair. DDX1 also acts as a transcriptional coactivator to facilitate NF-κB mediated gene activation. Elevated expression of DDX1 was observed in a number of tumors such as retinoblastoma, neuroblastoma, and testicular carcinoma. The accumulation of DDX1 is associated with cancer metastasis and poor survival.

Pathways: Ribonucleoprotein Complex Subunit Organization