IL-31 antibody

Catalog No. ABIN2665158

Product Details anti-IL-31 Antibody

Target: IL-31 (IL31) (Interleukin 31 (IL31))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL-31 antibody is un-conjugated

Application: Biochemical Assay (BCA)

Purification: The antibody was purified by affinity chromatography.

Clone: 1D10B31

Isotype: IgG2b kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for IL-31

Target: IL-31 (IL31) (Interleukin 31 (IL31))

Alternative Name: IL-31 (IL31 Products)

Synonyms: IL-31 antibody, 1700013B14Rik antibody, IL31 antibody, interleukin 31 antibody, IL31 antibody, Il31 antibody

Background: IL-31, produced mainly by activated CD4+ T cells, is a newly discovered helical cytokine belonging to the gp130/IL6 cytokine family. IL-31 is closely related in structure to IL-6, IL-11, and IL-27. Binding of IL-31 to its receptor activates JAK/STAT, PI3K/AKT, and MAPK pathways. IL-31 acts on a broad range of immune and non-immune cells and thus possesses potential pleiotropic physiological functions, such as regulating hematopoiesis and immune response. Human IL-31 is also involved in inflammatory bowel disease, airway hypersensitivity, and dermatitis.