Reacts with the cytoplasmic domain of a 47 kDa membrane glycoprotein present on B lymphocytes, also referred to as mb-1. It is expressed on B cells at various stages of differentiation, from pre-B cell stage, probably before expression of cytoplasmic μ chain, to plasma cell stage, in which it is detected only in the cytoplasm. CD79a associates with CD79b to form part of the B-cell receptor complex. It has been suggested that CD79a may play a role in mediating the transport of IgM to the cell surface. This antibody has been found to react on permeabilized A20 cells (mouse B cell line). Profile of permeabilized peripheral blood lymphocytes with Cytofix/Cytoperm (Cat# 554714) analyzed on a FACScan
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
Store undiluted at 4°C.
Mason, Cordell, Tse, van Dongen, van Noesel, Micklem, Pulford, Valensi, Comans-Bitter, Borst: "The IgM-associated protein mb-1 as a marker of normal and neoplastic B cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 147, Issue 11, pp. 2474-82, (1991) (PubMed).
Sakaguchi, Kashiwamura, Kimoto, Thalmann, Melchers: "B lymphocyte lineage-restricted expression of mb-1, a gene with CD3-like structural properties." in: The EMBO journal, Vol. 7, Issue 11, pp. 3457-64, (1989) (PubMed).
Target
CD79a (CD79A)
(B-cell antigen receptor complex-associated protein alpha chain (CD79A))