INPP5D antibody (C-Term)

Catalog No. ABIN2774303

Product Details anti-INPP5D Antibody

Target: INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INPP5D antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PPTPTPRPPL PVKSPAVLHL QHSKGRDYRD NTELPHHGKH RPEEGPPGPL

Predicted Reactivity: Cow: 86%, Dog: 86%, Guinea Pig: 79%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against INPP5D. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1189 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for INPP5D

Target: INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

Alternative Name: INPP5D (INPP5D Products)

Synonyms: INPP5D antibody, 256.t00004 antibody, 13.t00027 antibody, ship antibody, ship1 antibody, AI323613 antibody, SHIP antibody, SHIP-1 antibody, SHIP1 antibody, s-SHIP antibody, SIP-145 antibody, hp51CN antibody, inositol polyphosphate-5-phosphatase D antibody, phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 antibody, inositol polyphosphate 5-phosphatase antibody, inositol polyphosphate-5-phosphatase D L homeolog antibody, INPP5D antibody, LOC100446045 antibody, inpp5d antibody, EHI_159880 antibody, EHI_153490 antibody, inpp5d.L antibody, LOC100380693 antibody, Inpp5d antibody

Background: This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Alias Symbols: MGC104855, MGC142140, MGC142142, SHIP, SHIP1, SIP-145, hp51CN
Protein Interaction Partner: NOTCH2NL, KRTAP10-3, KRTAP10-9, KRTAP10-7, KRT40, KHDRBS3, KRT31, DAB1, SH3KBP1, XIAP, INPPL1, LRRK1, SHC1, PTPN11, UBASH3B, CD2AP, SYK, NCK1, GRB2, CBL, UBC, ARAP1, BCR, CLYBL, MME, EPOR, TRIP10, CD300LF, DOK3, LILRB4, INPP5D, FCGR2B, GAB2, DOK2, GAB1, D
Protein Size: 1189

Molecular Weight: 131 kDa

Gene ID: 3635

NCBI Accession: NM_001017915, NP_001017915

UniProt: Q92835

Pathways: TCR Signaling, BCR Signaling, Warburg Effect