KIR3DL1 antibody (Middle Region)

Catalog No. ABIN2775346

Product Details anti-KIR3DL1 Antibody

Target: KIR3DL1 (Killer Cell Immunoglobulin-Like Receptor, three Domains, Long Cytoplasmic Tail, 1 (KIR3DL1))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIR3DL1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EHFFLHKEGI SKDPSRLVGQ IHDGVSKANF SIGPMMLALA GTYRCYGSVT

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against KIR3DL1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human KIR3DL1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for KIR3DL1

Target: KIR3DL1 (Killer Cell Immunoglobulin-Like Receptor, three Domains, Long Cytoplasmic Tail, 1 (KIR3DL1))

Alternative Name: KIR3DL1 (KIR3DL1 Products)

Synonyms: KIR3DL1 antibody, KIR3DL3 antibody, CD158E1 antibody, KIR antibody, KIR3DL1/S1 antibody, NKAT3 antibody, NKB1 antibody, NKB1B antibody, Kirl1 antibody, Kirl2 antibody, Krl1 antibody, killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 antibody, uncharacterized LOC100437736 antibody, killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1 antibody, KIR3DL1 antibody, LOC100437736 antibody, Kir3dl1 antibody

Background: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules, thus, KIR proteins are thought to play an important role in regulation of the immune response.
Alias Symbols: CD158E1, KIR, KIR3DL1/S1, NKAT3, NKB1, NKB1B
Protein Interaction Partner: env, RPS6KB1, HLA-B, CDK3,
Protein Size: 444

Molecular Weight: 48 kDa

Gene ID: 3811

NCBI Accession: NM_013289, NP_037421

UniProt: P43629