GNB2L1 antibody (N-Term)

Catalog No. ABIN2778965

Product Details anti-GNB2L1 Antibody

Target: GNB2L1 (Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 2-Like 1 (GNB2L1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Rabbit, Sheep, Zebrafish (Danio rerio), Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GNB2L1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: ISSDGQFALS GSWDGTLRLW DLTTGTTTRR FVGHTKDVLS VAFSSDNRQI

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Yeast: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against GNB2L1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GNB2L1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 317 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GNB2L1

Target: GNB2L1 (Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 2-Like 1 (GNB2L1))

Alternative Name: GNB2L1 (GNB2L1 Products)

Synonyms: MGC53289 antibody, GNB2L1 antibody, AL033335 antibody, GB-like antibody, Gnb2-rs1 antibody, Rack1 antibody, p205 antibody, RACK1 antibody, H12.3 antibody, HLC-7 antibody, PIG21 antibody, rack1 antibody, wu:fb80d08 antibody, wu:fk65d12 antibody, gnb2-rs1 antibody, h12.3 antibody, hlc-7 antibody, pig21 antibody, C12-3 antibody, c12.3 antibody, guanine nucleotide binding protein, beta 2, related sequence 1 antibody, receptor for activated C kinase 1 antibody, guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 antibody, receptor for activated C kinase 1 L homeolog antibody, Guanine nucleotide-binding protein subunit beta-2-like 1 antibody, gnb2l1 antibody, RACK1 antibody, Rack1 antibody, rack1.L antibody, rack-1 antibody

Background: GNB2L1 seems to bind protein kinase C acting as an intracellular receptor to anchor the activated PKC to the cytoskeleton. GNB2L1 may be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and ITGB1, GNB2L1 serves as a platform for SRC activation or inactivation. GNB2L1 may play an important role in the developing brain and neuronal differentiation.
Alias Symbols: Gnb2-rs1, H12.3, HLC-7, PIG21, RACK1
Protein Interaction Partner: MKRN2, LARP4B, HUWE1, UBC, SUMO2, HIF1A, STAU1, TARDBP, ADRB2, PRKCB, TRIM45, RNF2, EZH2, BMI1, SUZ12, rev, PTOV1, RPS8, RPS6, RPS5, RPS3A, RPS27L, EIF3K, SYNCRIP, DYNLL1, RPS3, RPSA, EIF3E, DYNC1LI2, RPS9, RPS27, RPS21, RPS20, RPS18, RPS16, RPS13, RPS12,
Protein Size: 317

Molecular Weight: 35 kDa

Gene ID: 10399

NCBI Accession: NM_006098, NP_006089

UniProt: P63244

Pathways: cAMP Metabolic Process, Positive Regulation of Endopeptidase Activity