HAND2 antibody (C-Term)

Catalog No. ABIN2779346

Product Details anti-HAND2 Antibody

Target: HAND2 (Heart and Neural Crest Derivatives Expressed 2 (HAND2))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Zebrafish (Danio rerio), Horse, Cow, Dog, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HAND2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: DQNGEAEAFK AEIKKTDVKE EKRKKELNEI LKSTVSSNDK KTKGRTGWPQ

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 87%

Characteristics: This is a rabbit polyclonal antibody against Hand2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 217 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HAND2

Target: HAND2 (Heart and Neural Crest Derivatives Expressed 2 (HAND2))

Alternative Name: Hand2 (HAND2 Products)

Synonyms: DHAND2 antibody, Hed antibody, Thing2 antibody, bHLHa26 antibody, dHand antibody, dhand2 antibody, hand2 antibody, xhand2 antibody, hand2-b antibody, Hand2' antibody, dHAND antibody, HAND2 antibody, hed antibody, dhand antibody, thing2 antibody, LOC100218345 antibody, AI225906 antibody, AI661148 antibody, Ehand2 antibody, Th2 antibody, zdHAND antibody, zgc:103415 antibody, Hand2 antibody, heart and neural crest derivatives expressed 2 antibody, heart and neural crest derivatives expressed 2 L homeolog antibody, heart and neural crest derivatives expressed 2 S homeolog antibody, HAND2 antibody, Hand2 antibody, hand2.L antibody, hand2.S antibody, hand2 antibody

Background: Hand2 is essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. It is required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. It plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Hand2 is involved in the development of branchial arches, which give rise to unique structures in the head and neck.
Alias Symbols: AI225906, AI661148, Ehand2, Hed, Th2, Thing2, bHLHa26, dHAND
Protein Interaction Partner: Nkx2-5, Hand1, Tcf3, Tcf4, Tcf12, Hoxd13, Twist1,
Protein Size: 217

Molecular Weight: 24 kDa

Gene ID: 15111

NCBI Accession: NM_010402, NP_034532

UniProt: Q61039

Pathways: Tube Formation, Feeding Behaviour