SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12) (Middle Region) antibody

Details for Product No. ABIN2779689, Supplier: Log in to see
Antigen
Epitope
Middle Region
7
5
4
3
2
2
2
2
2
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus)
78
34
6
5
3
3
3
2
2
1
1
1
Host
Rabbit
49
34
Clonality
Polyclonal
Application
Chromatin Immunoprecipitation (ChIP), Immunohistochemistry (IHC), Western Blotting (WB)
78
43
21
9
8
8
8
3
3
3
2
1
1
Options
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Immunogen The immunogen is a synthetic peptide directed towards the middle region of human SUZ12
Blocking Peptide Blocking peptide for this product available: ABIN984652
Sequence TGETNDKSTA PIAKPLATRN SESLHQENKP GSVKPTQTIA VKESLTTDLQ
Predicted Reactivity Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
Characteristics This is a rabbit polyclonal antibody against SUZ12. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name SUZ12
Background A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors. Translocation t (7,17)(p15,q21) with JAZF1 generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer.This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. The specific function of this gene has not yet been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CHET9, JJAZ1, KIAA0160
Protein Interaction Partner: FBXW11, EZH2, BRCA1, CDK5RAP2, RBM22, LUC7L, NHP2, H2AFY2, C17orf85, NAT10, ATAD3A, HEATR1, PTCD3, CHCHD3, CDKAL1, DDX56, GDAP1, LUC7L3, SF3B6, LUC7L2, NOP58, LIMA1, CDC40, CRNKL1, HP1BP3, STOML2, TRA2A, RBM15B, REPIN1, PRPF19, AKAP8L, TBL2, DAZAP1, PHGDH
Protein Size: 739
Molecular Weight 83 kDa
Gene ID 23512
NCBI Accession NM_015355, NP_056170
UniProt Q15022
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 739 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Immunohistochemistry (IHC) image for anti-SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12) (Middle Region) antibody (ABIN2779689) anti-SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12) (Middle Region) antibody
Chromatin Immunoprecipitation (ChIP) image for anti-SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12) (Middle Region) antibody (ABIN2779689) Chromatin Immunoprecipitation (ChIP) Using SUZ12 Antibody - middle region (ARP32515_P...
Background publications Li, Ma, Wang, Koontz, Nucci, Sklar: "Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 50, pp. 20001-6, 2007 (PubMed).