SOX9 antibody (SRY (Sex Determining Region Y)-Box 9) (C-Term)

Details for Product anti-SOX9 Antibody No. ABIN2780338, Supplier: Log in to see
Antigen
  • LOC100227849
  • SOX9
  • CMD1
  • CMPD1
  • SRA1
  • SOX-9
  • 2010306G03Rik
  • AV220920
  • mKIAA4243
  • SRY (sex determining region Y)-box 9
  • SRY (sex determining region Y)-box 10
  • SRY-box containing gene 9
  • SOX9
  • LOC100227849
  • SOX10
  • Sox9
Alternatives
anti-Human SOX9 antibody for Dot Blot
Epitope
C-Term
18
16
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9
9
6
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2
2
1
1
1
1
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1
1
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1
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus), Zebrafish
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60
39
15
9
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Host
Rabbit
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6
Clonality
Polyclonal
Conjugate
This SOX9 antibody is un-conjugated
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2
1
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Application
Flow Cytometry (FACS), Western Blotting (WB)
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29
21
14
8
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1
1
Options
Supplier
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Supplier Product No.
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Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human SOX9
Blocking Peptide Blocking peptide for this product available: ABIN984286
Sequence AGQGTGLYST FTYMNPAQRP MYTPIADTSG VPSIPQTHSP QHWEQPVYTQ
Predicted Reactivity Cow: 86%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%
Characteristics This is a rabbit polyclonal antibody against SOX9. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name SOX9 (SOX9 Antibody Abstract)
Background SOX9 recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal.The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CMD1, CMPD1, SRA1
Protein Interaction Partner: ZBTB7A, SCX, HERC1, UBC, SOX9, ATP6V1H, ctnnb1-a, RUNX2, SMAD3, SMAD2, EP300, CREB3L4, SPEN, KPNB1, TRAF2, CREBBP, MED12, NR5A1, MAF, HSPA1A, CREB1,
Protein Size: 509
Molecular Weight 56 kDa
Gene ID 6662
NCBI Accession NM_000346, NP_000337
UniProt P48436
Research Area Organogenesis, Reproduction, Lineage Markers, Transcription Factors
Pathways EGFR Signaling Pathway, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 509 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-SRY (Sex Determining Region Y)-Box 9 (SOX9) (C-Term) antibody (ABIN2780338) WB Suggested Anti-SOX9 Antibody Titration: 0.2-1 ug/ml
Positive Control:...
Product cited in: Lau, Lee, Chang: "Conserved sex-specific timing of meiotic initiation during sex differentiation in the protandrous black porgy Acanthopagrus schlegelii." in: Biology of reproduction, Vol. 88, Issue 6, pp. 150, 2013 (PubMed).

Background publications Vidal, Ortonne, Schedl: "SOX9 expression is a general marker of basal cell carcinoma and adnexal-related neoplasms." in: Journal of cutaneous pathology, Vol. 35, Issue 4, pp. 373-9, 2008 (PubMed).

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