SLC11A1 antibody (C-Term)

Catalog No. ABIN2781545

Product Details anti-SLC11A1 Antibody

Target: SLC11A1 (Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 1 (SLC11A1))

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse, Cow, Guinea Pig, Rabbit, Goat, Horse, Sheep, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC11A1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VLLTRSCAIL PTVLVAVFRD LRDLSGLNDL LNVLQSLLLP FAVLPILTFT

Predicted Reactivity: Cow: 100%, Dog: 93%, Goat: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Sheep: 93%

Characteristics: This is a rabbit polyclonal antibody against SLC11A1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SLC11A1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 550 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-SLC11A1 antibody (ABIN2781545)

Usuda, Kono, Hayashi, Kawasaki, Mitsui, Shibutani, Dote, Adachi, Fujihara, Shimbo, Sun, Lu, Nakasuji: "Determination of reference concentrations of strontium in urine by inductively coupled plasma atomic emission spectrometry." in: Environmental health and preventive medicine, Vol. 11, Issue 1, pp. 11-6, (2011) (PubMed).

Target Details for SLC11A1

Target: SLC11A1 (Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 1 (SLC11A1))

Alternative Name: SLC11A1 (SLC11A1 Products)

Synonyms: SLC11A1 antibody, NRAMP1 antibody, LSH antibody, NRAMP antibody, Bcg antibody, Itg antibody, Lsh antibody, Nramp1 antibody, Ity antibody, Nramp antibody, ity antibody, BCG antibody, solute carrier family 11 member 1 L homeolog antibody, solute carrier family 11 member 1 antibody, solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 antibody, slc11a1.L antibody, SLC11A1 antibody, Slc11a1 antibody

Background: SLC11A1 is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and is a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in its gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease.
Alias Symbols: LSH, NRAMP, NRAMP1
Protein Size: 550

Molecular Weight: 61 kDa

Gene ID: 6556

NCBI Accession: NM_000578, NP_000569

UniProt: P49279

Pathways: Transition Metal Ion Homeostasis, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus