PILRB antibody (Middle Region)

Catalog No. ABIN2782794

Product Details anti-PILRB Antibody

Target: PILRB (Paired Immunoglobin-Like Type 2 Receptor beta (PILRB))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PILRB antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: KLTITQAVTT TTTWRPSSTT TIAGLRVTES KGHSESWHLS LDTAIRVALA

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against PILRB. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PILRB

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 227 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PILRB

Target: PILRB (Paired Immunoglobin-Like Type 2 Receptor beta (PILRB))

Alternative Name: PILRB (PILRB Products)

Synonyms: FDFACT1 antibody, FDFACT2 antibody, FDFACT antibody, Fdact antibody, Pilrb antibody, paired immunoglobin-like type 2 receptor beta antibody, paired immunoglobin-like type 2 receptor beta 1 antibody, PILRB antibody, Pilrb1 antibody, Pilrb antibody

Background: Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the non-ITIM-bearing member of the receptor pair, which has a truncated cytoplasmic tail relative to its ITIM-bearing partner and functions in the activating role. Alternative splicing has been observed at this locus and three variants, encoding two distinct isoforms, are described. Additional transcript variants have been identified but their full-length nature has not been determined.
Alias Symbols: FDFACT1, FDFACT2
Protein Interaction Partner: BRCA1, ABHD16A, SAMSN1, PTPN6, PTPN11, LYN,
Protein Size: 227

Molecular Weight: 23 kDa

Gene ID: 29990

NCBI Accession: NM_013440, NP_038468

UniProt: Q9UKJ0