MGA (C-Term) antibody

Catalog No. ABIN2783018

Product Details

Target: MGA

Binding Specificity: C-Term

Reactivity: Human, Pig, Rabbit, Rat, Cow, Dog, Horse, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Sequence: ASLQMKRESQ NPDQKDETNS IKREQETKKV LQSEGEAVDP EANVIKQNSG

Predicted Reactivity: Cow: 92%, Dog: 85%, Horse: 92%, Human: 100%, Mouse: 79%, Pig: 92%, Rabbit: 79%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against MGA. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human MGA

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details

Target: MGA

Background: MGA functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes and functions as a repressor or an activator. It binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. It suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. It function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor
Protein Interaction Partner: SUMO2, SUMO3, EED, RNF2, MAX, SMAD1, LSM8, UBC, CD2BP2, CBX2, PCGF6, RYBP, PCGF3, YAF2, CBX4, CBX3, E2F4, E2F3, E2F1,
Protein Size: 697

Molecular Weight: 76 kDa

Gene ID: 23269