MAP4K2 antibody (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2) (N-Term)

Details for Product anti-MAP4K2 Antibody No. ABIN2783442, Supplier: Log in to see
Antigen
  • BL44
  • GCK
  • RAB8IP
  • AI385662
  • Rab8ip
  • mitogen activated protein kinase kinase kinase kinase 2
  • mitogen-activated protein kinase kinase kinase kinase 2
  • Map4k2
  • MAP4K2
  • map4k2
Epitope
N-Term
26
15
14
14
7
4
4
3
2
2
2
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rat (Rattus), Zebrafish
59
40
11
3
3
3
2
2
2
2
2
1
Host
Rabbit
74
2
Clonality
Polyclonal
Conjugate
This MAP4K2 antibody is un-conjugated
6
6
6
6
6
6
Application
Western Blotting (WB)
70
49
17
14
5
4
2
2
2
1
Options
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Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human MAP4K2
Blocking Peptide Blocking peptide for this product available: ABIN979784
Sequence TVTSELAAVK IVKLDPGDDI SSLQQEITIL RECRHPNVVA YIGSYLRNDR
Predicted Reactivity Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 86%
Characteristics This is a rabbit polyclonal antibody against MAP4K2. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name MAP4K2 (MAP4K2 Antibody Abstract)
Background MAP4K2 is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.
Alias Symbols: BL44, GCK, RAB8IP
Protein Interaction Partner: HSP90AA1, UBC, MAP3K11, MAP3K1, POT1, MCM3AP-AS1, NACAD, SNRNP35, PRDX4, SERPINA4, HNRNPA2B1, XRCC6, DEFB1, TRAF2, RAB8A, MAP2K4,
Protein Size: 820
Molecular Weight 91 kDa
Gene ID 5871
NCBI Accession NM_004579, NP_004570
UniProt Q12851
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 820 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) (N-Term) antibody (ABIN2783442) WB Suggested Anti-MAP4K2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer:
Background publications Wissing, Jänsch, Nimtz, Dieterich, Hornberger, Kéri, Wehland, Daub: "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 3, pp. 537-47, 2007 (PubMed).

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