DYNC1I2 antibody (N-Term)

Catalog No. ABIN2784706

Product Details anti-DYNC1I2 Antibody

Target: DYNC1I2 (Dynein, Cytoplasmic 1, Intermediate Chain 2 (DYNC1I2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DYNC1I2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VAPKPPIEPE EEKTLKKDEE NDSKAPPHEL TEEEKQQILH SEEFLSFFDH

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 92%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against DYNC1I2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DYNC1I2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 638 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DYNC1I2

Target: DYNC1I2 (Dynein, Cytoplasmic 1, Intermediate Chain 2 (DYNC1I2))

Alternative Name: DYNC1I2 (DYNC1I2 Products)

Synonyms: dnci2 antibody, dncic1 antibody, ic2 antibody, dync1i2 antibody, im:7147021 antibody, zgc:153318 antibody, 3110079H08Rik antibody, AW554389 antibody, Dncic2 antibody, Dnci2 antibody, DNCI2 antibody, IC2 antibody, dynein, cytoplasmic 1, intermediate chain 2 antibody, dynein, cytoplasmic 1, intermediate chain 2 S homeolog antibody, dynein cytoplasmic 1 intermediate chain 2 antibody, dynein, cytoplasmic 1, intermediate chain 2a antibody, dync1i2 antibody, dync1i2.S antibody, DYNC1I2 antibody, dync1i2a antibody, Dync1i2 antibody

Background: DYNC1I2 acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes.
Alias Symbols: DNCI2, FLJ21089, FLJ90842, IC2, MGC104199, MGC111094, MGC9324
Protein Interaction Partner: DYNLRB1, TUBGCP3, SUMO2, UBC, RNF2, EIF3CL, PRUNE2, DYNC1LI1, EIF3K, SERBP1, HNRNPA0, AKAP12, EIF3G, EIF3B, EIF3A, RPS26, RPS13, RPS5, PSMD8, PSMC5, YBX1, MAP2, DYNC1LI2, DYNC1H1, DDX1, ABCF1, vpr, PEX14, VCP, ECT2, CUL3, Dynll1, Dync1i2, SRRM2, DCTN1, PN
Protein Size: 638

Molecular Weight: 71 kDa

Gene ID: 1781

NCBI Accession: NM_001378, NP_001369

UniProt: Q13409

Pathways: M Phase