MPP7 antibody (N-Term)

Catalog No. ABIN2785310

Product Details anti-MPP7 Antibody

Target: MPP7 (Membrane Protein, Palmitoylated 7 (MAGUK p55 Subfamily Member 7) (MPP7))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Horse, Rabbit, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MPP7 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MPALSTGSGS DTGLYELLAA LPAQLQPHVD SQEDLTFLWD MFGEKSLHSL

Predicted Reactivity: Cow: 100%, Dog: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against MPP7. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MPP7

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 576 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-MPP7 antibody (ABIN2785310)

Stucke, Timmerman, Vandekerckhove, Gevaert, Hall: "The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation." in: Molecular biology of the cell, Vol. 18, Issue 5, pp. 1744-55, (2007) (PubMed).

Target Details for MPP7

Target: MPP7 (Membrane Protein, Palmitoylated 7 (MAGUK p55 Subfamily Member 7) (MPP7))

Alternative Name: MPP7 (MPP7 Products)

Synonyms: 1110068J02Rik antibody, 2810038M04Rik antibody, 5430426E14Rik antibody, AI415104 antibody, Gm955 antibody, dlg3 antibody, hmp antibody, membrane palmitoylated protein 7 antibody, membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) antibody, membrane protein, palmitoylated 7a (MAGUK p55 subfamily member 7) antibody, MPP7 antibody, Mpp7 antibody, mpp7a antibody

Background: MPP7 acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. MPP7 is involved in the assembly of protein complexes at sites of cell-cell contact.Membrane-associated guanylate kinases (MAGUKs) are important adaptor proteins involved in the assembly of protein complexes at sites of cell-cell contact. They are found in synapses, adherens junctions, and tight junctions. All MAGUKs contain at least 1 PDZ domain, an SH3 domain, and a GUK domain, and many contain 1 or 2 L27 domains, which are involved in multimerization of MAGUKs. MPP7 belongs to the p55 stardust subfamily of MAGUKs, which is named for a Drosophila gene required for establishment of cell polarity in the developing fly embryo (Bohl et al., 2007 [PubMed 17237226]).[supplied by OMIM].
Alias Symbols: FLJ32798, RP11-218D6.5
Protein Interaction Partner: AMOT, Wwtr1, Yap1, UBC,
Protein Size: 576

Molecular Weight: 65 kDa

Gene ID: 143098

NCBI Accession: NM_173496, NP_775767

UniProt: Q5T2T1

Pathways: Cell-Cell Junction Organization