Dynamitin antibody (Dynactin 2 (p50)) (N-Term)

Details for Product anti-DCTN2 Antibody No. ABIN2787686, Supplier: Log in to see
Antigen
  • DCTN2
  • dctn2
  • dctn50
  • dynamitin
  • rbp50
  • CG8269
  • DMN
  • Dmel\\CG8269
  • P50
  • dDyn
  • dmn
  • dyna
  • l(2)k16109
  • l(2)k16218
  • p50
  • p50/Dmn
  • p50/dynamitin
  • 2310042E05Rik
  • C130077D06Rik
  • C87049
  • DCTN-50
  • GMP23-48K
  • RBP50
  • DCTN50
  • DYNAMITIN
  • zgc:63867
  • dynactin 2 (p50)
  • Dynamitin
  • dynactin 2
  • DCTN2
  • dctn2-b
  • Dmn
  • dctn2
  • Dctn2
  • dctn2-a
Alternatives
anti-Human Dynamitin antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
N-Term
7
4
4
4
4
3
3
2
1
1
1
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rabbit, Rat (Rattus), Zebrafish
73
45
37
3
2
2
2
2
2
1
1
1
1
1
Host
Rabbit
63
7
4
Clonality
Polyclonal
Conjugate
This Dynamitin antibody is un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
58
21
18
13
10
9
3
3
1
1
1
1
Options
Supplier
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Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human DCTN2
Blocking Peptide Blocking peptide for this product available: ABIN975637
Sequence ADPKYADLPG IARNEPDVYE TSDLPEDDQA EFDAFAQELE ELTSTSVEHI
Predicted Reactivity Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
Characteristics This is a rabbit polyclonal antibody against DCTN2. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name DCTN2 (DCTN2 Antibody Abstract)
Background DCTN2 is a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place.This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: DCTN50, DYNAMITIN, RBP50
Protein Interaction Partner: KIFC3, CCDC172, HAUS1, BLOC1S6, DCTN2, BICD2, DYNC1I1, DCTN1, UBC, FLNB, NUP43, LEO1, SEH1L, ACTR10, DCTN4, DCTN3, ACTR1A, ACTR1B, RABEP1, LMNB1, GADD45A, KPNA2, SMURF1, DYNLRB1, STRN4, RANBP9, TPM4, SNRPA1, PSMD4, PSMD1, PSMC4, PSMC2, POLR2D, POLR2A, MCM
Protein Size: 406
Molecular Weight 45 kDa
Gene ID 10540
NCBI Accession NM_006400, NP_006391
UniProt Q13561
Pathways M Phase, Ribonucleoprotein Complex Subunit Organization
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 406 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-Dynactin 2 (p50) (DCTN2) (N-Term) antibody (ABIN2787686) WB Suggested Anti-DCTN2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer:
Background publications Camargo, Collura, Rain, Mizuguchi, Hermjakob, Kerrien, Bonnert, Whiting, Brandon: "Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia." in: Molecular psychiatry, Vol. 12, Issue 1, pp. 74-86, 2006 (PubMed).

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