GLP2R antibody (N-Term)

Catalog No. ABIN2787698

Product Details anti-GLP2R Antibody

Target: GLP2R (Glucagon-Like Peptide 2 Receptor (GLP2R))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GLP2R antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: KLGSSRAGPG RGSAGLLPGV HELPMGIPAP WGTSPLSFHR KCSLWAPGRP

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against GLP2R. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GLP2R

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 553 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-GLP2R antibody (ABIN2787698)

Sams, Hastrup, Andersen, Thim: "Naturally occurring glucagon-like peptide-2 (GLP-2) receptors in human intestinal cell lines." in: European journal of pharmacology, Vol. 532, Issue 1-2, pp. 18-23, (2006) (PubMed).

Target Details for GLP2R

Target: GLP2R (Glucagon-Like Peptide 2 Receptor (GLP2R))

Alternative Name: GLP2R (GLP2R Products)

Synonyms: 9530092J08Rik antibody, GLP-2 antibody, glucagon like peptide 2 receptor antibody, glucagon-like peptide 2 receptor antibody, GLP2R antibody, Glp2r antibody

Background: The GLP2 receptor (GLP2R) is a G protein-coupled receptor superfamily member closely related to the glucagon receptor ans GLP1 receptor. Glucagon-like peptide-2 (GLP2) is a 33-amino acid proglucagon-derived peptide produced by intestinal enteroendocrine cells. Like glucagon-like peptide-1 (GLP1) and glucagon itself, it is derived from the proglucagon peptide encoded by the GCG gene. GLP2 stimulates intestinal growth and upregulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. Moreover, GLP2 prevents intestinal hypoplasia resulting from total parenteral nutrition. GLP2R, a G protein-coupled receptor superfamily member is expressed in the gut and closely related to the glucagon receptor (GCGR) and the receptor for GLP1 (GLP1R). The GLP2 receptor (GLP2R) is a G protein-coupled receptor superfamily member closely related to the glucagon receptor ans GLP1 receptor. Glucagon-like peptide-2 (GLP2) is a 33-amino acid proglucagon-derived peptide produced by intestinal enteroendocrine cells. Like glucagon-like peptide-1 (GLP1) and glucagon itself, it is derived from the proglucagon peptide encoded by the GCG gene. GLP2 stimulates intestinal growth and upregulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. Moreover, GLP2 prevents intestinal hypoplasia resulting from total parenteral nutrition. GLP2R, a G protein-coupled receptor superfamily member is expressed in the gut and closely related to the glucagon receptor (GCGR) and the receptor for GLP1 (GLP1R).
Alias Symbols: -
Protein Interaction Partner: UBC, GCG, CALM1,
Protein Size: 553

Molecular Weight: 61 kDa

Gene ID: 9340

NCBI Accession: NM_004246, NP_004237

UniProt: O95838

Pathways: Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, cAMP Metabolic Process, Feeding Behaviour