USP7 antibody (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated)) (Middle Region)

Details for Product anti-USP7 Antibody No. ABIN2787924, Supplier: Log in to see
Antigen
  • CG1490
  • Dmel\\CG1490
  • USP7
  • 2210010O09Rik
  • AA409944
  • AA617399
  • AU019296
  • AW548146
  • C80752
  • Hausp
  • HAUSP
  • TEF1
  • UBP
  • ubiquitin-specific protease 7
  • ubiquitin specific peptidase 7 (herpes virus-associated)
  • ubiquitin specific peptidase 7
  • Usp7
  • usp7
  • USP7
Epitope
Middle Region
32
24
21
15
13
8
7
6
5
5
5
4
2
2
2
2
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rabbit, Rat (Rattus), Zebrafish
208
44
41
15
12
9
7
5
4
3
3
3
2
2
1
1
1
1
1
1
Host
Rabbit
111
97
1
Clonality
Polyclonal
Conjugate
This USP7 antibody is un-conjugated
8
8
8
4
4
4
4
4
3
3
3
3
3
3
3
3
3
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
181
65
64
50
48
33
13
13
7
5
3
3
1
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human USP7
Blocking Peptide Blocking peptide for this product available: ABIN985997
Sequence RVLLDNVENK MKGTCVEGTI PKLFRGKMVS YIQCKEVDYR SDRREDYYDI
Predicted Reactivity Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%
Characteristics This is a rabbit polyclonal antibody against USP7. It was validated on Western Blot.
Purification Affinity Purified
Alternative Name USP7 (USP7 Antibody Abstract)
Background USP7 is a hydrolase that deubiquitinates target proteins such as FOXO4, TP53, MDM2, PTEN and DAXX. Together with DAXX, USP7 prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and proteasomal degradation. USP7 deubiquitinates TP53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2, and also induces TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, USP7 is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. USP7 is involved in cell proliferation during early embryonic development. USP7 contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection.
Alias Symbols: HAUSP, TEF1
Protein Interaction Partner: UBC, TP53, CHFR, RNF220, TPP1, FAM175B, HUWE1, PEPD, XPC, SUMO2, IKBKG, SHFM1, RB1, SUMO1, RPA3, RPA2, RPA1, PTEN, EED, ABL1, RNF2, MMS19, PPP6C, FKBP5, PPP6R3, CDC37, OGFR, COPS6, MAGED2, TRAP1, MCMBP, CLK3, UHRF1, PPARG, RNF11, KAT5, SOX2, LOC576779, HD
Protein Size: 1102
Molecular Weight 128 kDa
Gene ID 7874
NCBI Accession NM_003470, NP_003461
UniProt Q93009
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 1102 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (Middle Region) antibody (ABIN2787924) Host: Rat Target Name: USP7 Sample Tissue: Rat Brain Antibody Dilution: 1ug/ml
Western Blotting (WB) image for anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (Middle Region) antibody (ABIN2787924) WB Suggested Anti-USP7 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive ...
Product cited in: Nie, Zhang, Dai, Zhang, Zhao, Xu, Chen, Wang, Wang, Qiao: "Nicotine Induced Murine Spermatozoa Apoptosis via Up-Regulation of Deubiquitinated RIP1 by Trim27 Promoter Hypomethylation." in: Biology of reproduction, Vol. 94, Issue 2, pp. 31, 2016 (PubMed).

Did you look for something else?